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Catalog Number:
02569
CAS Number:
142994-19-2
Fmoc-4-chloro-D-phenylalanine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-D-Phe(4-Cl)-OH, Fmoc-p-chloro-D-Phe-OH, (R)-Fmoc-2-amino-3-(4-chlorophenyl)propionic acid
Documents
$20.00 /1G
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Product Information

Fmoc-4-chloro-D-phenylalanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during solid-phase peptide synthesis. Its unique structure, characterized by the presence of a 4-chlorophenyl group, enhances its reactivity and stability, making it an ideal choice for researchers looking to create complex peptides with precision.

In pharmaceutical research, Fmoc-4-chloro-D-phenylalanine serves as a building block for the synthesis of bioactive peptides, which can be pivotal in developing therapeutic agents targeting various diseases. Its application extends to the fields of biochemistry and molecular biology, where it aids in the exploration of peptide interactions and functions. Researchers appreciate its ability to facilitate the synthesis of peptides with improved efficacy and specificity, thereby advancing the development of novel therapeutics.

Synonyms
Fmoc-D-Phe(4-Cl)-OH, Fmoc-p-chloro-D-Phe-OH, (R)-Fmoc-2-amino-3-(4-chlorophenyl)propionic acid
CAS Number
142994-19-2
Purity
≥ 98% (HPLC)
Molecular Formula
C24H20ClNO4
Molecular Weight
421.9
MDL Number
MFCD00077066
Melting Point
173 - 206 ?C (Lit.)
Appearance
White powder
Optical Rotation
[a]D20 = 28 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-D-Phe(4-Cl)-OH, Fmoc-p-chloro-D-Phe-OH, (R)-Fmoc-2-amino-3-(4-chlorophenyl)propionic acid
CAS Number
142994-19-2
Purity
≥ 98% (HPLC)
Molecular Formula
C24H20ClNO4
Molecular Weight
421.9
MDL Number
MFCD00077066
Melting Point
173 - 206 ?C (Lit.)
Appearance
White powder
Optical Rotation
[a]D20 = 28 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-4-chloro-D-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound is a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the creation of complex peptide structures.
  • Drug Development: Its unique properties make it valuable in the pharmaceutical industry for developing new drugs, especially those targeting specific receptors or enzymes.
  • Bioconjugation: The chemical can be used in bioconjugation techniques to attach peptides to other molecules, enhancing the delivery and efficacy of therapeutic agents.
  • Research in Neuroscience: It is employed in studies related to neurotransmitter systems, helping researchers understand the role of peptides in brain function and disorders.
  • Protein Engineering: The compound aids in modifying proteins to improve their stability and activity, which is crucial for biotechnological applications.

Citations