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Catalog Number:
02547
CAS Number:
94744-50-0
Fmoc-ॅ-aminoisobutyric acid
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-Aib-OH, Fmoc-α-methylalanine
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Product Information

Fmoc-a-aminoisobutyric acid is a versatile building block widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which allows for selective deprotection during the synthesis of peptides, making it an essential tool for chemists in the pharmaceutical industry. Its unique structure not only enhances the stability of the peptide chains but also facilitates the introduction of various amino acids, thereby expanding the potential for creating complex peptide sequences.

Researchers appreciate Fmoc-a-aminoisobutyric acid for its ability to improve the solubility and bioavailability of peptides, which is crucial in developing therapeutic agents. Its application extends to the synthesis of cyclic peptides and peptidomimetics, which are increasingly important in drug design due to their enhanced stability and activity. With its reliable performance and compatibility with various coupling reagents, this compound stands out as a preferred choice for professionals aiming to innovate in peptide chemistry.

Synonyms
Fmoc-Aib-OH, Fmoc-α-methylalanine
CAS Number
94744-50-0
Purity
≥ 98% (HPLC)
Molecular Formula
C19H19NO4
Molecular Weight
325.37
MDL Number
MFCD00151913
PubChem ID
2756096
Melting Point
175 - 185 °C
Appearance
White to off-white powder
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-Aib-OH, Fmoc-α-methylalanine
CAS Number
94744-50-0
Purity
≥ 98% (HPLC)
Molecular Formula
C19H19NO4
Molecular Weight
325.37
MDL Number
MFCD00151913
PubChem ID
2756096
Melting Point
175 - 185 °C
Appearance
White to off-white powder
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-a-aminoisobutyric acid is widely utilized in research focused on

  • Peptide Synthesis: This compound serves as a protecting group in the synthesis of peptides, allowing for the selective modification of amino acids. Its stability under various conditions makes it a preferred choice in solid-phase peptide synthesis.
  • Drug Development: In pharmaceutical research, it plays a crucial role in the design of peptide-based drugs, enhancing their stability and bioavailability. This application is particularly valuable in developing therapeutics for complex diseases.
  • Bioconjugation: Fmoc-a-aminoisobutyric acid is used in bioconjugation processes, where it helps attach biomolecules to surfaces or other molecules, facilitating the development of targeted drug delivery systems.
  • Research in Material Science: It is applied in creating functional materials, such as hydrogels, which can be used in tissue engineering and regenerative medicine, offering benefits in biocompatibility and mechanical properties.
  • Protein Engineering: The compound aids in the modification of proteins to study structure-function relationships, enabling researchers to explore new functionalities and improve enzyme activity.

Citations