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Catalog Number:
02482
CAS Number:
128107-47-1
Fmoc-O-tert-butyl-D-serine
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-D-Ser(tBu)-OH
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$28.04 /1G
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Product Information

Fmoc-O-tert-butyl-D-serine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (fluorenylmethyloxycarbonyl) group, which facilitates the selective modification of amino acids during solid-phase peptide synthesis. Its tert-butyl ester group enhances solubility and stability, making it an ideal choice for researchers aiming to create complex peptide structures with improved yields and purity. Fmoc-O-tert-butyl-D-serine is particularly valuable in the development of peptide-based therapeutics, where precise control over amino acid sequences is crucial for biological activity.

In addition to its role in peptide synthesis, Fmoc-O-tert-butyl-D-serine can be employed in various research applications, including the study of protein interactions and the design of novel biomaterials. Its unique properties allow for easy cleavage of the protecting groups under mild conditions, ensuring that the integrity of the peptide is maintained. This compound stands out for its efficiency and reliability in producing high-quality peptides, making it a preferred choice among professionals in the pharmaceutical and biotechnology sectors.

Synonyms
Fmoc-D-Ser(tBu)-OH
CAS Number
128107-47-1
Purity
≥ 99% (HPLC)
Molecular Formula
C22H25NO5
Molecular Weight
383.4
MDL Number
MFCD00077071
Melting Point
125 - 140 °C (Lit.)
Appearance
White powder or crystalline powder
Optical Rotation
[a]D20 = -26 ± 3 º (C = 1 in EtOAc)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-D-Ser(tBu)-OH
CAS Number
128107-47-1
Purity
≥ 99% (HPLC)
Molecular Formula
C22H25NO5
Molecular Weight
383.4
MDL Number
MFCD00077071
Melting Point
125 - 140 °C (Lit.)
Appearance
White powder or crystalline powder
Optical Rotation
[a]D20 = -26 ± 3 º (C = 1 in EtOAc)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-tert-butyl-D-serine is widely utilized in research focused on:

  • Peptide Synthesis: This compound is a key building block in the synthesis of peptides. Its protective groups facilitate the stepwise assembly of amino acids, making it easier for chemists to create complex peptide structures.
  • Drug Development: In pharmaceutical research, it helps in designing peptide-based drugs. The stability and solubility of the compound enhance the bioavailability of therapeutic peptides, crucial for effective drug formulation.
  • Bioconjugation: Fmoc-O-tert-butyl-D-serine is used in bioconjugation techniques, allowing researchers to attach biomolecules to surfaces or other molecules. This application is vital in creating targeted drug delivery systems.
  • Protein Engineering: It plays a significant role in modifying proteins to improve their functionality or stability. This is particularly important in the biotechnology sector, where engineered proteins can lead to better industrial enzymes or therapeutic proteins.
  • Research in Neuroscience: The compound is utilized in studies related to neuropeptides, which are important for understanding brain function and developing treatments for neurological disorders.

Citations