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Catalog Number:
02479
CAS Number:
104091-08-9
Fmoc-D-glutamic acid γ-tert-butyl ester
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-D-Glu(OtBu)-OH, Fmoc-D-glutamic acid 5-tert-butyl ester
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Product Information

Fmoc-D-glutamic acid g-tert-butyl ester is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which facilitates the selective coupling of amino acids in solid-phase peptide synthesis, making it an essential building block for researchers in the fields of biochemistry and medicinal chemistry. Its tert-butyl ester group enhances solubility and stability, allowing for more efficient reactions and improved yields in various synthesis processes.

In addition to its role in peptide synthesis, Fmoc-D-glutamic acid g-tert-butyl ester is also valuable in the development of pharmaceuticals and biologically active compounds. Its unique structure allows for the creation of complex molecules with specific biological activities, making it a preferred choice for researchers aiming to design targeted therapeutics. The compound's favorable properties, such as its stability and ease of use, position it as a key reagent in both academic and industrial laboratories focused on peptide and drug development.

Synonyms
Fmoc-D-Glu(OtBu)-OH, Fmoc-D-glutamic acid 5-tert-butyl ester
CAS Number
104091-08-9
Purity
≥ 99% (HPLC)
Molecular Formula
C24H27NO6
Molecular Weight
425.5
MDL Number
MFCD00077055
Melting Point
80 - 100 °C (Lit.)
Appearance
White powder
Optical Rotation
[a]D20 = 8.5 ± 2 ° (C=1 in MeOH)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-D-Glu(OtBu)-OH, Fmoc-D-glutamic acid 5-tert-butyl ester
CAS Number
104091-08-9
Purity
≥ 99% (HPLC)
Molecular Formula
C24H27NO6
Molecular Weight
425.5
MDL Number
MFCD00077055
Melting Point
80 - 100 °C (Lit.)
Appearance
White powder
Optical Rotation
[a]D20 = 8.5 ± 2 ° (C=1 in MeOH)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-D-glutamic acid g-tert-butyl ester is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing for the creation of complex and functional peptides used in various biological studies.
  • Drug Development: It plays a crucial role in the design of pharmaceutical compounds, especially in the development of drugs targeting neurological disorders, due to its structural similarity to neurotransmitters.
  • Bioconjugation: The compound is used in bioconjugation processes, where it helps attach biomolecules to surfaces or other molecules, enhancing the efficacy of drug delivery systems.
  • Research in Protein Engineering: It is employed in the modification of proteins, allowing researchers to study protein interactions and functions, which is essential in biotechnology and therapeutic development.
  • Analytical Chemistry: This chemical is utilized in analytical methods for the detection and quantification of amino acids and peptides, providing valuable insights in quality control and research laboratories.

Citations