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Catalog Number:
02465
CAS Number:
118488-18-9
Fmoc-O-tert-butyl-D-tyrosine
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Fmoc-D-Tyr(tBu)-OH
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Product Information

Fmoc-O-tert-butyl-D-tyrosine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during solid-phase peptide synthesis (SPPS). Its tert-butyl group enhances solubility and stability, making it an ideal choice for researchers focused on synthesizing complex peptides and proteins. The unique structure of Fmoc-O-tert-butyl-D-tyrosine allows for efficient coupling reactions, facilitating the creation of bioactive peptides that can be used in pharmaceuticals, diagnostics, and research applications.

This compound is particularly beneficial for those in the fields of medicinal chemistry and biochemistry, as it enables the development of peptide-based therapeutics with improved efficacy and stability. Its application extends to the synthesis of peptide libraries for drug discovery, where the ability to modify and optimize peptide sequences is crucial. With its favorable properties, Fmoc-O-tert-butyl-D-tyrosine stands out as a valuable tool for researchers aiming to innovate in peptide synthesis and therapeutic development.

Synonyms
Fmoc-D-Tyr(tBu)-OH
CAS Number
118488-18-9
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C28H29NO5
Molecular Weight
459.5
MDL Number
MFCD00065684
Melting Point
145 - 160 ºC
Appearance
White powder
Optical Rotation
[a]D20 = 28.5 ± 2.5 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-D-Tyr(tBu)-OH
CAS Number
118488-18-9
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C28H29NO5
Molecular Weight
459.5
MDL Number
MFCD00065684
Melting Point
145 - 160 ºC
Appearance
White powder
Optical Rotation
[a]D20 = 28.5 ± 2.5 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-tert-butyl-D-tyrosine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS). Its protective groups allow for selective reactions, enhancing the efficiency of peptide assembly.
  • Drug Development: In pharmaceutical research, it is used to create peptide-based drugs. The stability and solubility provided by its structure can lead to more effective therapeutic agents.
  • Bioconjugation: The chemical is valuable in bioconjugation processes, where it helps attach peptides to other biomolecules, improving the delivery and efficacy of drugs in targeted therapies.
  • Research in Neuroscience: Fmoc-O-tert-butyl-D-tyrosine is used in studies related to neuropeptides, aiding in the understanding of neurological pathways and potential treatments for neurodegenerative diseases.
  • Custom Peptide Libraries: It is instrumental in creating diverse peptide libraries for screening in drug discovery, allowing researchers to identify potential leads more efficiently.

Citations