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Catalog Number:
02462
CAS Number:
86123-11-7
Nα-Fmoc-D-tryptophan
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-D-Trp-OH
Documents
$22.03 /1G
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Product Information

Na-Fmoc-D-tryptophan is a versatile amino acid derivative widely utilized in peptide synthesis and pharmaceutical research. This compound features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which allows for selective deprotection during the synthesis of peptides, making it an essential building block for researchers in the field of medicinal chemistry. Its unique structure not only enhances the stability of the peptide chains but also improves solubility, facilitating easier handling and manipulation in laboratory settings.

In practical applications, Na-Fmoc-D-tryptophan is particularly valuable in the development of bioactive peptides and drug candidates, especially those targeting neurological disorders due to tryptophan's role as a precursor to serotonin. Its ability to incorporate into various peptide sequences while maintaining structural integrity makes it a preferred choice among professionals seeking to optimize their synthesis processes. This compound stands out for its efficiency in producing high-purity peptides, which are crucial for therapeutic applications and research.

Synonyms
Fmoc-D-Trp-OH
CAS Number
86123-11-7
Purity
≥ 99% (HPLC)
Molecular Formula
C26H22N2O4
Molecular Weight
426.5
MDL Number
MFCD00062954
PubChem ID
7567764
Melting Point
178-192 ?C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = +29 ± 2º (C=1 in DMF)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-D-Trp-OH
CAS Number
86123-11-7
Purity
≥ 99% (HPLC)
Molecular Formula
C26H22N2O4
Molecular Weight
426.5
MDL Number
MFCD00062954
PubChem ID
7567764
Melting Point
178-192 ?C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = +29 ± 2º (C=1 in DMF)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-D-tryptophan is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the incorporation of D-tryptophan residues into peptides.
  • Drug Development: Its role in medicinal chemistry is significant, as it can be used to design and develop novel therapeutic agents, especially those targeting neurological disorders due to tryptophan's involvement in serotonin production.
  • Biotechnology: In the field of biotechnology, it is utilized to create modified proteins that can enhance enzyme activity or stability, making it valuable for industrial applications.
  • Research on Neurotransmitters: This compound aids in studying the effects of tryptophan on neurotransmitter levels, which is crucial for understanding mood disorders and developing antidepressant therapies.
  • Fluorescent Labeling: Na-Fmoc-D-tryptophan can be used in the development of fluorescent probes, which are essential for tracking biological processes in live cells, providing insights into cellular functions.

Citations