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Catalog Number:
02461
CAS Number:
35737-15-6
Nα-Fmoc-L-tryptophan
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Fmoc-L-Trp-OH
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Product Information

Na-Fmoc-L-tryptophan is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which allows for selective deprotection during the synthesis of peptides, making it an essential building block for researchers in the fields of biochemistry and medicinal chemistry. Its unique structure not only enhances the stability of the amino acid during synthesis but also improves the solubility of the resulting peptides, facilitating easier purification and characterization.

In practical applications, Na-Fmoc-L-tryptophan is particularly valuable in the development of pharmaceuticals targeting neurological disorders, as tryptophan is a precursor to serotonin, a key neurotransmitter. Additionally, its use in the synthesis of peptide-based therapeutics has shown promise in cancer treatment and other therapeutic areas. Researchers appreciate its reliability and efficiency in producing high-quality peptides, making it a preferred choice in laboratories focused on peptide chemistry and drug discovery.

Synonyms
Fmoc-L-Trp-OH
CAS Number
35737-15-6
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C26H22N2O4
Molecular Weight
426.5
MDL Number
MFCD00037126
PubChem ID
100107
Melting Point
180 - 190 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = - 29 ± 2 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Trp-OH
CAS Number
35737-15-6
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C26H22N2O4
Molecular Weight
426.5
MDL Number
MFCD00037126
PubChem ID
100107
Melting Point
180 - 190 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = - 29 ± 2 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-L-tryptophan is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing researchers to create complex molecules with specific biological functions.
  • Drug Development: It plays a crucial role in the pharmaceutical industry for developing new drugs, particularly those targeting neurological disorders, due to its structural similarity to neurotransmitters.
  • Bioconjugation: Na-Fmoc-L-tryptophan is used in bioconjugation processes, where it helps attach drugs or imaging agents to biomolecules, enhancing their therapeutic efficacy and targeting capabilities.
  • Protein Engineering: In the field of protein engineering, this compound aids in modifying proteins to improve their stability and functionality, which is essential for biotechnological applications.
  • Research on Tryptophan Metabolism: It is instrumental in studies investigating tryptophan metabolism and its effects on mood and behavior, providing insights into mental health research.

Citations