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Catalog Number:
02460
CAS Number:
71989-35-0
Fmoc-O-tert-butyl-L-threonine
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Fmoc-L-Thr(tBu)-OH
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Product Information

Fmoc-O-tert-butyl-L-threonine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethoxycarbonyl) group, which allows for selective deprotection during the synthesis of complex peptides. Its tert-butyl ester group enhances solubility and stability, making it an excellent choice for researchers working in organic chemistry and biochemistry. Fmoc-O-tert-butyl-L-threonine is particularly valuable in the synthesis of therapeutic peptides, where precise control over amino acid sequences is crucial for biological activity.

In practical applications, this compound is often employed in solid-phase peptide synthesis (SPPS), facilitating the efficient assembly of peptides with high purity and yield. Its unique properties allow for the incorporation of L-threonine into peptides, which can be essential for achieving desired biological functions. Researchers appreciate its compatibility with various coupling reagents and its ability to streamline the synthesis process, ultimately leading to faster and more efficient development of peptide-based therapeutics.

Synonyms
Fmoc-L-Thr(tBu)-OH
CAS Number
71989-35-0
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C23H27NO5
Molecular Weight
397.5
MDL Number
MFCD00077075
PubChem ID
3085672
Melting Point
125 - 135 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = 16 ± 2 ° (C=1 in EtOAc)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Thr(tBu)-OH
CAS Number
71989-35-0
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C23H27NO5
Molecular Weight
397.5
MDL Number
MFCD00077075
PubChem ID
3085672
Melting Point
125 - 135 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = 16 ± 2 ° (C=1 in EtOAc)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-tert-butyl-L-threonine is widely utilized in research focused on:

  • Peptide Synthesis: This chemical serves as a key building block in the synthesis of peptides, allowing researchers to create complex structures with specific functionalities, enhancing the development of new drugs.
  • Protein Engineering: It is used in the modification of proteins, aiding in the design of proteins with improved stability and activity, which is crucial in biotechnology and pharmaceutical applications.
  • Drug Development: The compound plays a significant role in the formulation of therapeutics, particularly in creating targeted delivery systems that improve the efficacy of medications.
  • Bioconjugation: It facilitates the attachment of biomolecules to other entities, such as drugs or imaging agents, enhancing the precision of therapeutic interventions and diagnostic tools.
  • Research in Chemical Biology: This compound is instrumental in studying biological processes, providing insights into enzyme mechanisms and cellular functions, which can lead to novel therapeutic strategies.

Citations