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Catalog Number:
02452
CAS Number:
73724-45-5
Fmoc-L-serine
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Fmoc-L-Ser-OH, Fmoc-L-β-hydroxyalanine, (S-Fmoc-2-amino-3-hydroxypropionic acid
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Product Information

Fmoc-L-serine is a versatile amino acid derivative widely utilized in peptide synthesis and bioconjugation applications. This compound features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which allows for selective deprotection during the synthesis of peptides, making it an essential building block for researchers in the fields of medicinal chemistry and biotechnology. Its unique structure not only enhances stability but also facilitates the incorporation of serine into peptides, which is crucial for the development of therapeutic proteins and biomolecules.

In addition to its role in peptide synthesis, Fmoc-L-serine is also valuable in the study of protein interactions and enzyme mechanisms, providing insights into biological processes. Its solubility in common organic solvents and compatibility with various coupling reagents make it an ideal choice for both academic and industrial applications. Researchers and professionals can leverage Fmoc-L-serine to streamline their synthesis processes, improve yields, and enhance the functionality of their peptide products.

Synonyms
Fmoc-L-Ser-OH, Fmoc-L-β-hydroxyalanine, (S-Fmoc-2-amino-3-hydroxypropionic acid
CAS Number
73724-45-5
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C18H17NO5
Molecular Weight
327.3
MDL Number
MFCD00051928
PubChem ID
7015325
Melting Point
~ 95 ºC
Appearance
White powder
Optical Rotation
[a]D20 = - 12 ± 2 º (C=1 in DMF)
Conditions
Store at RT
General Information
Synonyms
Fmoc-L-Ser-OH, Fmoc-L-β-hydroxyalanine, (S-Fmoc-2-amino-3-hydroxypropionic acid
CAS Number
73724-45-5
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C18H17NO5
Molecular Weight
327.3
MDL Number
MFCD00051928
PubChem ID
7015325
Melting Point
~ 95 ºC
Appearance
White powder
Optical Rotation
[a]D20 = - 12 ± 2 º (C=1 in DMF)
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-serine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protective group in solid-phase peptide synthesis, allowing for the selective modification of amino acids while preventing unwanted reactions.
  • Bioconjugation: It is used in the development of bioconjugates, facilitating the attachment of biomolecules to surfaces or other molecules, which is crucial in drug delivery systems.
  • Protein Engineering: Researchers employ Fmoc-L-serine in the design of novel proteins with enhanced properties, aiding in the creation of therapeutic proteins and enzymes.
  • Analytical Chemistry: This chemical is utilized in various analytical techniques, such as chromatography, to separate and analyze complex mixtures of amino acids and peptides.
  • Pharmaceutical Development: It plays a role in the synthesis of pharmaceutical compounds, particularly those targeting neurological disorders, due to its structural similarity to neurotransmitters.

Citations