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Catalog Number:
02424
CAS Number:
122996-47-8
Fmoc-O-tert-butyl-L-trans-4-hydroxyproline
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-L-Hyp(tBu)-OH
Documents
$25.00 /1G
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Product Information

Fmoc-O-tert-butyl-L-trans-4-hydroxyproline is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which allows for selective deprotection during the synthesis process, making it an invaluable tool for chemists working in the field of medicinal chemistry. Its unique structure, characterized by the tert-butyl group, enhances solubility and stability, facilitating its use in various organic reactions.

Researchers and industry professionals can leverage Fmoc-O-tert-butyl-L-trans-4-hydroxyproline in the design of bioactive peptides, particularly in the development of therapeutics targeting neurological disorders and other diseases. Its ability to provide a stable backbone while allowing for functional group modifications makes it an ideal candidate for creating complex peptide libraries. Additionally, its favorable properties compared to other amino acid derivatives can lead to improved yields and purities in peptide synthesis, making it a preferred choice for both academic and industrial applications.

Synonyms
Fmoc-L-Hyp(tBu)-OH
CAS Number
122996-47-8
Purity
≥ 99% (HPLC)
Molecular Formula
C24H27NO5
Molecular Weight
409.48
MDL Number
MFCD00151930
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -25 ± 2 º (C=1 in MeOH)
Conditions
Store at ≤ 4 °C
General Information
Synonyms
Fmoc-L-Hyp(tBu)-OH
CAS Number
122996-47-8
Purity
≥ 99% (HPLC)
Molecular Formula
C24H27NO5
Molecular Weight
409.48
MDL Number
MFCD00151930
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -25 ± 2 º (C=1 in MeOH)
Conditions
Store at ≤ 4 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-tert-butyl-L-trans-4-hydroxyproline is widely utilized in research focused on:

  • Peptide Synthesis: This compound is commonly used as a building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, due to its stability and ease of removal during deprotection steps.
  • Drug Development: It plays a crucial role in the development of pharmaceuticals, especially in creating compounds that target specific biological pathways, enhancing the efficacy of drug candidates.
  • Bioconjugation: The chemical is valuable in bioconjugation processes, allowing researchers to attach biomolecules to surfaces or other molecules, which is essential for creating targeted therapies and diagnostics.
  • Protein Engineering: In protein engineering, it helps in modifying proteins to improve their stability and functionality, making it easier to design proteins with desired characteristics for industrial applications.
  • Research in Structural Biology: It is utilized in the study of protein structures, aiding in the understanding of protein folding and interactions, which is vital for advancing knowledge in biochemistry and molecular biology.

Citations