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Catalog Number:
02423
CAS Number:
88050-17-3
Fmoc-L-trans-4-hydroxyproline
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-L-Hyp-OH, Fmoc-(2S,4R-4-hydroxypyrrolidine-2-carboxylicacid
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Product Information

Fmoc-L-trans-4-hydroxyproline is a valuable amino acid derivative widely utilized in peptide synthesis and pharmaceutical research. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which enhances its stability and solubility, making it an ideal choice for solid-phase peptide synthesis. Its unique structure allows for the incorporation of hydroxyl groups into peptides, which can significantly influence the biological activity and properties of the resulting compounds. Researchers often leverage Fmoc-L-trans-4-hydroxyproline to create peptides with enhanced stability and bioactivity, particularly in the development of therapeutics targeting various diseases.

In addition to its applications in peptide synthesis, Fmoc-L-trans-4-hydroxyproline is also explored for its potential in materials science and drug delivery systems. Its ability to form stable secondary structures can be advantageous in designing biomaterials with specific mechanical properties. Furthermore, the compound's compatibility with various coupling reagents and its ease of use in synthetic protocols make it a preferred choice among professionals in the field. With its diverse applications and beneficial properties, Fmoc-L-trans-4-hydroxyproline stands out as a crucial component in advancing research and development in biochemistry and pharmaceuticals.

Synonyms
Fmoc-L-Hyp-OH, Fmoc-(2S,4R-4-hydroxypyrrolidine-2-carboxylicacid
CAS Number
88050-17-3
Purity
≥ 99% (HPLC)
Molecular Formula
C20H19NO5
Molecular Weight
353.4
MDL Number
MFCD00151929
PubChem ID
2756109
Melting Point
186-196 °C
Appearance
White powder
Optical Rotation
[a]D20 = - 58 ± 3 º (C=1 in MeOH)
Conditions
Store at 0-8°C
General Information
Synonyms
Fmoc-L-Hyp-OH, Fmoc-(2S,4R-4-hydroxypyrrolidine-2-carboxylicacid
CAS Number
88050-17-3
Purity
≥ 99% (HPLC)
Molecular Formula
C20H19NO5
Molecular Weight
353.4
MDL Number
MFCD00151929
PubChem ID
2756109
Melting Point
186-196 °C
Appearance
White powder
Optical Rotation
[a]D20 = - 58 ± 3 º (C=1 in MeOH)
Conditions
Store at 0-8°C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-trans-4-hydroxyproline is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in the creation of modified peptides that require specific stereochemistry for biological activity.
  • Drug Development: It is used in the pharmaceutical industry to develop new drugs, especially those targeting collagen-related diseases, due to its structural similarity to proline.
  • Biomaterials: In tissue engineering, it is incorporated into hydrogels and scaffolds, enhancing the mechanical properties and biocompatibility of materials used for cell growth and regeneration.
  • Research on Protein Folding: This compound aids researchers in studying protein folding and stability, providing insights into how modifications can affect protein behavior.
  • Cosmetic Formulations: It is also found in cosmetic products aimed at improving skin elasticity and hydration, leveraging its properties to enhance formulations.

Citations