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Catalog Number:
02396
CAS Number:
86060-81-3
Fmoc-S-acetamidomethyl-L-cysteine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-Cys(Acm)-OH
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Product Information

Fmoc-S-acetamidomethyl-L-cysteine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethoxycarbonyl) group, which facilitates the selective modification of cysteine residues in peptides, enhancing stability and solubility. Its unique acetamidomethyl group provides additional protection against oxidation, making it an ideal choice for researchers focused on synthesizing complex peptides that require high purity and yield.

In the pharmaceutical industry, Fmoc-S-acetamidomethyl-L-cysteine is particularly valuable for the development of peptide-based therapeutics and bioconjugates, where precise control over amino acid functionality is crucial. Its application extends to the creation of novel drug candidates, where the incorporation of cysteine can enhance biological activity and target specificity. Researchers appreciate its ease of use in solid-phase peptide synthesis, allowing for streamlined workflows and improved efficiency in laboratory settings.

Synonyms
Fmoc-L-Cys(Acm)-OH
CAS Number
86060-81-3
Purity
≥ 98% (HPLC)
Molecular Formula
C21H22N2O5S
Molecular Weight
414.5
MDL Number
MFCD00038769
PubChem ID
4021455
Melting Point
145 - 160 ºC (Lit.)
Appearance
White powder
Optical Rotation
[a]D20 = -32 ± 1.2 º (C=1, MeOH)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Cys(Acm)-OH
CAS Number
86060-81-3
Purity
≥ 98% (HPLC)
Molecular Formula
C21H22N2O5S
Molecular Weight
414.5
MDL Number
MFCD00038769
PubChem ID
4021455
Melting Point
145 - 160 ºC (Lit.)
Appearance
White powder
Optical Rotation
[a]D20 = -32 ± 1.2 º (C=1, MeOH)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-S-acetamidomethyl-L-cysteine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), enabling researchers to create complex peptide structures efficiently.
  • Drug Development: Its unique properties make it valuable in the pharmaceutical industry for developing new drugs, especially those targeting specific proteins or enzymes.
  • Bioconjugation: The compound is used in bioconjugation processes, allowing for the attachment of biomolecules to surfaces or other molecules, which is crucial in creating targeted therapies and diagnostics.
  • Research in Protein Engineering: It plays a significant role in protein engineering, where modifications can enhance protein stability and activity, leading to better therapeutic outcomes.
  • Analytical Chemistry: Fmoc-S-acetamidomethyl-L-cysteine is employed in analytical techniques to study protein interactions and modifications, providing insights into biological processes.

Citations