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Catalog Number:
02380
CAS Number:
157774-30-6
Nα-Fmoc-Nω-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-D-arginine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-D-Arg(Pmc)-OH
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Product Information

Na-Fmoc-Nw-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-D-arginine is a specialized amino acid derivative that serves as a crucial building block in peptide synthesis and drug development. This compound is particularly valued in the field of medicinal chemistry for its unique sulfonyl group, which enhances the stability and solubility of peptides. Its Fmoc (9-fluorenylmethoxycarbonyl) protecting group allows for easy incorporation into peptide chains while facilitating selective deprotection, making it an ideal choice for researchers focused on synthesizing complex peptides with high purity and yield.

In addition to its role in peptide synthesis, this compound has potential applications in the development of targeted therapeutics, particularly in the design of peptide-based drugs that require specific modifications for enhanced bioactivity. The incorporation of the pentamethylchroman moiety not only contributes to the compound's stability but also may improve its pharmacokinetic properties. Researchers and industry professionals can leverage the unique features of Na-Fmoc-Nw-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-D-arginine to advance their work in drug discovery and development, making it a valuable addition to any chemical toolkit.

Synonyms
Fmoc-D-Arg(Pmc)-OH
CAS Number
157774-30-6
Purity
≥ 98% (HPLC)
Molecular Formula
C35H42N4O7S
Molecular Weight
662.8
MDL Number
MFCD00065619
Appearance
White to off-white powder
Optical Rotation
=+3.0º to +5.0º (c=1, DMF)
Conditions
Store at 0-8°C
General Information
Synonyms
Fmoc-D-Arg(Pmc)-OH
CAS Number
157774-30-6
Purity
≥ 98% (HPLC)
Molecular Formula
C35H42N4O7S
Molecular Weight
662.8
MDL Number
MFCD00065619
Appearance
White to off-white powder
Optical Rotation
=+3.0º to +5.0º (c=1, DMF)
Conditions
Store at 0-8°C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-Nw-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-D-arginine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protective group in solid-phase peptide synthesis, allowing for the selective modification of amino acids without interfering with other functional groups.
  • Drug Development: It plays a crucial role in the design of peptide-based therapeutics, particularly in enhancing the stability and bioavailability of drug candidates.
  • Bioconjugation: The sulfonyl group facilitates the conjugation of peptides to various biomolecules, aiding in the development of targeted drug delivery systems.
  • Research in Neuroscience: This compound is used in studies related to neuropeptides, contributing to the understanding of neurological functions and potential treatments for neurodegenerative diseases.
  • Analytical Chemistry: It is employed in the development of analytical methods for the detection and quantification of peptides, improving the accuracy and efficiency of biochemical assays.

Citations