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Catalog Number:
02064
CAS Number:
101555-62-8
Fmoc-D-proline
Purity:
≥ 99.9% (HPLC, Chiral purity)
Synonym(s):
Fmoc-D-Pro-OH, (R)-Fmoc-pyrrolidine-2-carboxylic acid
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Product Information

Fmoc-D-proline is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which enhances its stability and reactivity, making it an ideal choice for solid-phase peptide synthesis. Researchers appreciate Fmoc-D-proline for its ability to facilitate the formation of peptide bonds while maintaining the integrity of the proline residue, which is crucial for the structural conformation of peptides. Its unique properties allow for the synthesis of complex peptides with high purity and yield, making it invaluable in the fields of biochemistry and pharmaceutical research.

In addition to its applications in peptide synthesis, Fmoc-D-proline is also employed in the development of therapeutic agents, particularly in the design of cyclic peptides and peptidomimetics. Its ability to influence the secondary structure of peptides makes it a key player in the study of protein folding and function. Researchers and industry professionals benefit from using Fmoc-D-proline due to its efficiency in streamlining synthesis processes and enhancing the overall quality of peptide products.

Synonyms
Fmoc-D-Pro-OH, (R)-Fmoc-pyrrolidine-2-carboxylic acid
CAS Number
101555-62-8
Purity
≥ 99.9% (HPLC, Chiral purity)
Molecular Formula
C20H19NO4
Molecular Weight
337.4
MDL Number
MFCD00077067
PubChem ID
100106
Melting Point
110 - 118 °C
Appearance
White crystal or powder
Optical Rotation
[a]D20 = 30 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-D-Pro-OH, (R)-Fmoc-pyrrolidine-2-carboxylic acid
CAS Number
101555-62-8
Purity
≥ 99.9% (HPLC, Chiral purity)
Molecular Formula
C20H19NO4
Molecular Weight
337.4
MDL Number
MFCD00077067
PubChem ID
100106
Melting Point
110 - 118 °C
Appearance
White crystal or powder
Optical Rotation
[a]D20 = 30 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-D-proline is widely utilized in research focused on:

  • Peptide Synthesis: It serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the incorporation of proline residues with high efficiency.
  • Drug Development: Researchers use it to develop novel therapeutic peptides, enhancing the stability and bioavailability of drug candidates, which is crucial in pharmaceutical formulations.
  • Bioconjugation: Fmoc-D-proline is employed in bioconjugation strategies, facilitating the attachment of biomolecules to surfaces or other molecules, which is important in creating targeted drug delivery systems.
  • Protein Engineering: It is utilized in the design of modified proteins with specific functionalities, aiding in the development of enzymes or antibodies with enhanced properties for industrial and medical applications.
  • Research in Structural Biology: The compound plays a significant role in studying protein folding and stability, providing insights that are essential for understanding various biological processes.

Citations