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Catalog Number:
01964
CAS Number:
154445-77-9
Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydro-benzofuran-5-sulfonyl)-L-arginine
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-L-Arg(Pbf)-OH
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Product Information

Na-Fmoc-Nw-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine is a specialized amino acid derivative that plays a crucial role in peptide synthesis and drug development. This compound features a unique sulfonyl group, enhancing its reactivity and stability, making it an excellent choice for researchers focused on developing novel therapeutics. Its Fmoc (9-fluorenylmethoxycarbonyl) protection allows for easy incorporation into peptide chains while maintaining the integrity of the arginine side chain, which is essential for various biological functions.

This compound is particularly valuable in the fields of medicinal chemistry and biochemistry, where it can be utilized to create complex peptides with specific biological activities. Its unique structure provides advantages in selectivity and potency compared to other amino acid derivatives, making it a preferred choice for researchers aiming to optimize drug candidates. Additionally, Na-Fmoc-Nw-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine can be employed in the synthesis of peptide-based vaccines and targeted therapies, showcasing its versatility and potential in advancing pharmaceutical research.

Synonyms
Fmoc-L-Arg(Pbf)-OH
CAS Number
154445-77-9
Purity
≥ 99% (HPLC)
Molecular Formula
C34H40N4O7S
Molecular Weight
648.77
MDL Number
MFCD00235804
PubChem ID
5060264
Melting Point
132 °C (dec.)
Appearance
White to off-white powder
Optical Rotation
[a]D25 = -4 ± 3 º (C=4 in DMF)D20 = -4 ± 1 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Arg(Pbf)-OH
CAS Number
154445-77-9
Purity
≥ 99% (HPLC)
Molecular Formula
C34H40N4O7S
Molecular Weight
648.77
MDL Number
MFCD00235804
PubChem ID
5060264
Melting Point
132 °C (dec.)
Appearance
White to off-white powder
Optical Rotation
[a]D25 = -4 ± 3 º (C=4 in DMF)D20 = -4 ± 1 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-Nw-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protective group in peptide synthesis, allowing for the selective modification of amino acids. Its stability under various conditions makes it ideal for complex peptide sequences.
  • Drug Development: In pharmaceutical research, it aids in the design of peptide-based drugs, particularly those targeting specific receptors. Its unique structure enhances binding affinity and specificity.
  • Bioconjugation: The sulfonyl group allows for efficient conjugation with biomolecules, facilitating the development of targeted delivery systems in therapeutics, particularly in cancer treatment.
  • Research in Neuroscience: This compound can be used in studies related to neuropeptides, helping researchers understand signaling pathways and potential therapeutic targets for neurological disorders.
  • Analytical Chemistry: It is useful in the development of analytical methods for detecting and quantifying peptides in biological samples, providing insights into metabolic processes and disease states.

Citations