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Catalog Number:
01956
CAS Number:
84030-19-3
Nα-Fmoc-Nim-benzyl-L-histidine
Purity:
≥ 99% (HPLC, TLC)
Synonym(s):
Fmoc-L-His(Bzl)-OH
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Product Information

Na-Fmoc-Nim-benzyl-L-histidine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which allows for selective deprotection during the synthesis process, making it an essential building block for creating complex peptides. Its unique structure, characterized by the benzylimidazole side chain, enhances its stability and solubility, making it particularly valuable in pharmaceutical applications. Researchers often employ Na-Fmoc-Nim-benzyl-L-histidine in the development of peptide-based therapeutics, including those targeting various diseases and conditions, due to its ability to facilitate the formation of biologically active peptides.

In addition to its applications in drug development, Na-Fmoc-Nim-benzyl-L-histidine is also used in the study of protein interactions and enzyme activity, providing insights into biochemical pathways. Its favorable properties, such as high purity and reactivity, make it an ideal choice for researchers seeking reliable results in their experiments. With its significant role in advancing peptide chemistry, this compound stands out as a crucial tool for both academic and industrial applications.

Synonyms
Fmoc-L-His(Bzl)-OH
CAS Number
84030-19-3
Purity
≥ 99% (HPLC, TLC)
Molecular Formula
C28H25N3O4
Molecular Weight
467.5
MDL Number
MFCD00038537
PubChem ID
100110
Melting Point
169 - 180 °C
Appearance
White powder
Optical Rotation
[a]24D = 111 ± 2 º (C=1 in CHCl3)
Conditions
Store at RT
General Information
Synonyms
Fmoc-L-His(Bzl)-OH
CAS Number
84030-19-3
Purity
≥ 99% (HPLC, TLC)
Molecular Formula
C28H25N3O4
Molecular Weight
467.5
MDL Number
MFCD00038537
PubChem ID
100110
Melting Point
169 - 180 °C
Appearance
White powder
Optical Rotation
[a]24D = 111 ± 2 º (C=1 in CHCl3)
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-Nim-benzyl-L-histidine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing researchers to create complex peptide structures efficiently.
  • Drug Development: It plays a crucial role in the design of peptide-based drugs, offering a way to modify the properties of peptides for improved efficacy and stability in pharmaceutical applications.
  • Bioconjugation: The chemical is used in bioconjugation processes, where it helps attach peptides to other molecules, enhancing the delivery of therapeutics or imaging agents in biomedical research.
  • Protein Engineering: Researchers utilize this compound to modify histidine residues in proteins, which can improve their function or stability, making it valuable in the field of protein engineering.
  • Analytical Chemistry: It is employed in analytical methods to study protein interactions and dynamics, providing insights into biological processes and aiding in the development of new analytical techniques.

Citations