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Catalog Number:
00632
CAS Number:
329-98-6
Phenylmethylsulfonyl fluoride
Purity:
99 - 100% (GC)
Synonym(s):
α-Toluenesulfonyl fluoride, Benzenemethanesulfonyl fluoride, Benzylsulfonyl fluoride
Hazmat
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Product Information

Phenylmethylsulfonyl fluoride is a versatile chemical compound widely recognized for its utility in organic synthesis and pharmaceutical applications. This sulfonyl fluoride is particularly valuable as a reagent in the preparation of sulfonamides and other sulfonyl derivatives, making it an essential tool for researchers in medicinal chemistry. Its ability to selectively modify amines and alcohols enhances its appeal in the development of novel therapeutic agents. Additionally, Phenylmethylsulfonyl fluoride serves as an important intermediate in the synthesis of various agrochemicals, contributing to advancements in crop protection and pest management.

The compound's unique reactivity profile allows for the introduction of sulfonyl groups into complex organic molecules, facilitating the design of compounds with improved biological activity. Its stability under a range of conditions further supports its use in diverse chemical environments. Researchers and industry professionals can leverage Phenylmethylsulfonyl fluoride to streamline their synthetic pathways, ultimately accelerating the discovery and development of new drugs and agricultural products.

Synonyms
α-Toluenesulfonyl fluoride, Benzenemethanesulfonyl fluoride, Benzylsulfonyl fluoride
CAS Number
329-98-6
Purity
99 - 100% (GC)
Molecular Formula
C7H7FO2S
Molecular Weight
174.2
MDL Number
MFCD00007424
PubChem ID
4784
Melting Point
92 - 95 °C
Appearance
White crystalline solid
Conditions
Store at 0 - 8 °C
General Information
Synonyms
α-Toluenesulfonyl fluoride, Benzenemethanesulfonyl fluoride, Benzylsulfonyl fluoride
CAS Number
329-98-6
Purity
99 - 100% (GC)
Molecular Formula
C7H7FO2S
Molecular Weight
174.2
MDL Number
MFCD00007424
PubChem ID
4784
Melting Point
92 - 95 °C
Appearance
White crystalline solid
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Phenylmethylsulfonyl fluoride is widely utilized in research focused on:

  • Protein Modification: This compound is commonly used as a reagent to selectively modify proteins, particularly in studies involving enzyme inhibition. It helps researchers understand enzyme mechanisms and develop potential inhibitors.
  • Drug Development: In pharmaceutical research, it serves as a valuable tool for synthesizing sulfonamide compounds, which are essential in creating new drugs with improved efficacy and reduced side effects.
  • Biochemical Assays: It is employed in various biochemical assays to study the activity of serine proteases, aiding in the identification of potential therapeutic targets in diseases like cancer and inflammation.
  • Material Science: The compound is used in the development of specialty polymers and coatings, enhancing material properties such as chemical resistance and durability, which are crucial in industrial applications.
  • Environmental Analysis: It plays a role in environmental chemistry, particularly in the detection and analysis of sulfonyl fluoride compounds in various matrices, contributing to pollution monitoring and regulatory compliance.

Citations