Discover the new Chem-Impex: Where innovation starts with a bond.

Catalog Number:
00490
CAS Number:
98-59-9
4-Toluenesulfonyl chloride
Purity:
≥ 99% (Assay)
Synonym(s):
Tosyl chloride
Hazmat
Documents
$25.20 /250G
Pack Size Availability Price
Request Bulk Quote
Product Information

4-Toluenesulfonyl chloride is a versatile reagent widely utilized in organic synthesis and pharmaceutical development. Known for its high reactivity, this compound serves as an essential building block for sulfonamide synthesis, facilitating the introduction of sulfonyl groups into various organic molecules. Its applications extend to the production of intermediates in the synthesis of agrochemicals, dyes, and pharmaceuticals, making it invaluable in both research and industrial settings. The compound's ability to selectively react with amines and alcohols allows for the efficient formation of sulfonamides and sulfonate esters, which are crucial in the development of numerous bioactive compounds.

In addition to its synthetic utility, 4-Toluenesulfonyl chloride is favored for its stability and ease of handling, which enhances safety and efficiency in laboratory environments. Researchers appreciate its role in the preparation of protected amino acids and other derivatives, streamlining complex synthetic pathways. With its broad range of applications and significant advantages over similar reagents, 4-Toluenesulfonyl chloride remains a key player in the toolkit of chemists and industry professionals alike.

Synonyms
Tosyl chloride
CAS Number
98-59-9
Purity
≥ 99% (Assay)
Molecular Formula
C7H7ClO2S
Molecular Weight
190.65
MDL Number
MFCD00007450
PubChem ID
7397
Melting Point
65 - 69 ?C
Appearance
White crystalline powder
Boiling Point
134 ?C/10 mmHg (Lit.)
Conditions
Store at RT
General Information
Synonyms
Tosyl chloride
CAS Number
98-59-9
Purity
≥ 99% (Assay)
Molecular Formula
C7H7ClO2S
Molecular Weight
190.65
MDL Number
MFCD00007450
PubChem ID
7397
Melting Point
65 - 69 ?C
Appearance
White crystalline powder
Boiling Point
134 ?C/10 mmHg (Lit.)
Conditions
Store at RT
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

4-Toluenesulfonyl chloride is widely utilized in research focused on:

  • Synthesis of Sulfonamides: This compound is crucial in the production of sulfonamide drugs, which are important in treating bacterial infections. Its ability to form stable sulfonamide bonds makes it a preferred choice in pharmaceutical applications.
  • Reagent in Organic Chemistry: It serves as a versatile reagent for introducing sulfonyl groups into organic molecules, enhancing their reactivity and stability. This is particularly useful in the development of new materials and compounds in research laboratories.
  • Production of Dyes and Pigments: The chemical is employed in the dye industry to create vibrant colors. Its unique properties allow for the production of dyes that are both stable and effective, making it valuable for textile and printing applications.
  • Modification of Polymers: Used in polymer chemistry, it helps modify polymer structures to improve their properties, such as solubility and thermal stability. This application is significant in the development of advanced materials for various industrial uses.
  • Cross-Coupling Reactions: In synthetic organic chemistry, it facilitates cross-coupling reactions, which are essential for building complex molecules. This application is particularly beneficial in the fields of medicinal chemistry and materials science.

Citations