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Catalog Number:
00228
CAS Number:
71989-16-7
Nα-Fmoc-L-asparagine
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Fmoc-L-Asn-OH, Fmoc-(S)-2-aminosuccinic acid 4-amide
Documents
$19.73 /5G
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Product Information

Na-Fmoc-L-asparagine is a versatile amino acid derivative widely utilized in peptide synthesis and biochemistry. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of the amine group during the synthesis of peptides. Its unique structure allows for easy removal of the Fmoc group under mild conditions, making it an ideal choice for researchers looking to streamline their synthesis processes. Na-Fmoc-L-asparagine is particularly valuable in the development of pharmaceuticals, where precise amino acid sequences are crucial for the efficacy of peptide-based drugs.

In addition to its applications in drug development, Na-Fmoc-L-asparagine is also used in the production of peptide libraries for high-throughput screening in drug discovery. Its stability and compatibility with various coupling reagents enhance its utility in solid-phase peptide synthesis (SPPS), allowing for the efficient assembly of complex peptides. Researchers and industry professionals can benefit from its reliable performance and ease of use, making Na-Fmoc-L-asparagine a preferred choice in both academic and industrial settings.

Synonyms
Fmoc-L-Asn-OH, Fmoc-(S)-2-aminosuccinic acid 4-amide
CAS Number
71989-16-7
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C19H18N2O5
Molecular Weight
354.4
MDL Number
MFCD00037132
PubChem ID
100109
Melting Point
175 - 195 °C
Appearance
White powder
Optical Rotation
[a]D20 = -13 ± 3 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Asn-OH, Fmoc-(S)-2-aminosuccinic acid 4-amide
CAS Number
71989-16-7
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C19H18N2O5
Molecular Weight
354.4
MDL Number
MFCD00037132
PubChem ID
100109
Melting Point
175 - 195 °C
Appearance
White powder
Optical Rotation
[a]D20 = -13 ± 3 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-L-asparagine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing for the incorporation of asparagine residues. Its protective Fmoc group facilitates efficient coupling reactions.
  • Drug Development: In pharmaceutical research, it is used to create peptide-based drugs, particularly in areas targeting neurological disorders, where asparagine plays a crucial role in neurotransmission.
  • Bioconjugation: Na-Fmoc-L-asparagine is employed in bioconjugation techniques, linking peptides to various biomolecules, enhancing drug delivery systems and improving therapeutic efficacy.
  • Protein Engineering: This compound aids in the design of modified proteins with specific functionalities, which can be crucial for developing novel enzymes or therapeutic proteins.
  • Analytical Chemistry: It is used in analytical applications, such as mass spectrometry, to study peptide fragmentation patterns, helping researchers understand peptide behavior and stability.

Citations