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Catalog Number:
00191
CAS Number:
54-42-2
5-Iodo-2'-deoxyuridine
Purity:
≥ 99% (HPLC)
Synonym(s):
5-Iodo-dU, 1-(2-Deoxy-β-D-ribofuranosyl)-5-iodouracil
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Product Information

5-Iodo-2'-deoxyuridine is a halogenated nucleoside analog that plays a crucial role in molecular biology and pharmaceutical research. This compound is primarily utilized in the study of viral infections and cancer therapies due to its ability to inhibit DNA synthesis. By incorporating itself into the DNA of replicating cells, 5-Iodo-2'-deoxyuridine disrupts normal cellular processes, making it a valuable tool for researchers investigating the mechanisms of viral replication and tumor growth. Its unique properties allow it to serve as a selective marker in various experimental applications, particularly in the development of antiviral drugs and cancer treatments.

In addition to its applications in research, 5-Iodo-2'-deoxyuridine has been explored for its potential in therapeutic interventions. Its effectiveness in targeting rapidly dividing cells makes it a candidate for further studies in oncology and virology. Researchers appreciate its stability and compatibility with various experimental protocols, enhancing its utility in laboratory settings. The compound's ability to mimic natural nucleosides while providing distinct advantages in experimental outcomes positions it as a significant asset in both academic and industrial research environments.

Synonyms
5-Iodo-dU, 1-(2-Deoxy-β-D-ribofuranosyl)-5-iodouracil
CAS Number
54-42-2
Purity
≥ 99% (HPLC)
Molecular Formula
C9H11IN2O5
Molecular Weight
354.1
MDL Number
MFCD00134656
PubChem ID
3687
Melting Point
176 - 184 °C
Appearance
White to almost white crystalline powder
Optical Rotation
[a]D20 = 28 - 32 °
Conditions
Store at 0 - 8 °C
General Information
Synonyms
5-Iodo-dU, 1-(2-Deoxy-β-D-ribofuranosyl)-5-iodouracil
CAS Number
54-42-2
Purity
≥ 99% (HPLC)
Molecular Formula
C9H11IN2O5
Molecular Weight
354.1
MDL Number
MFCD00134656
PubChem ID
3687
Melting Point
176 - 184 °C
Appearance
White to almost white crystalline powder
Optical Rotation
[a]D20 = 28 - 32 °
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

5-Iodo-2'-deoxyuridine is widely utilized in research focused on:

  • Antiviral Research: This compound is effective in studying viral replication, particularly in the development of antiviral therapies against herpes simplex virus and other DNA viruses.
  • Cancer Treatment: It serves as a nucleoside analog in cancer research, helping to understand its role in inhibiting tumor cell proliferation and enhancing the efficacy of chemotherapy.
  • Genetic Studies: Researchers use it to explore DNA synthesis and repair mechanisms, providing insights into genetic disorders and potential therapeutic interventions.
  • Pharmaceutical Development: This compound is a valuable tool in drug formulation, particularly for creating targeted therapies that require precise nucleoside modifications.
  • Diagnostic Applications: It can be employed in molecular imaging techniques, aiding in the detection and monitoring of certain diseases through its incorporation into DNA.

Citations