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Catalog Number:
00177
CAS Number:
103213-32-7
Fmoc-S-trityl-L-cysteine
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-L-Cys(Trt)-OH, (R)-2-Fmoc-3-tritylsulfanyl-propionic acid
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Product Information

Fmoc-S-trityl-L-cysteine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethoxycarbonyl) group, which allows for selective deprotection during the synthesis of peptides, making it an essential building block for researchers in the field of medicinal chemistry. Its unique trityl (triphenylmethyl) group enhances stability and solubility, facilitating easier handling and manipulation in various chemical reactions.

In practical applications, Fmoc-S-trityl-L-cysteine is particularly valuable in the synthesis of peptides that require the incorporation of cysteine residues, which are crucial for forming disulfide bonds in protein structures. This compound is also employed in the development of targeted therapeutics and bioconjugates, where precise control over peptide sequences is paramount. Its ability to streamline the synthesis process while maintaining high purity and yield makes it a preferred choice among professionals in pharmaceutical and biotechnological research.

Synonyms
Fmoc-L-Cys(Trt)-OH, (R)-2-Fmoc-3-tritylsulfanyl-propionic acid
CAS Number
103213-32-7
Purity
≥ 99% (HPLC)
Molecular Formula
C37H31NO4S
Molecular Weight
585.7
MDL Number
MFCD00038538
PubChem ID
3746926
Melting Point
170 - 180 °C
Appearance
White powder
Optical Rotation
[a]D20 = 20 ± 2 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Cys(Trt)-OH, (R)-2-Fmoc-3-tritylsulfanyl-propionic acid
CAS Number
103213-32-7
Purity
≥ 99% (HPLC)
Molecular Formula
C37H31NO4S
Molecular Weight
585.7
MDL Number
MFCD00038538
PubChem ID
3746926
Melting Point
170 - 180 °C
Appearance
White powder
Optical Rotation
[a]D20 = 20 ± 2 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-S-trityl-L-cysteine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protecting group for cysteine residues in peptide synthesis, allowing for the selective modification of peptides without affecting other functional groups.
  • Drug Development: It plays a crucial role in the development of peptide-based drugs, particularly those targeting specific receptors or enzymes, enhancing their efficacy and stability.
  • Bioconjugation: Researchers use it in bioconjugation strategies, linking peptides to various biomolecules, which is essential in creating targeted therapies and diagnostics.
  • Protein Engineering: The compound aids in the design of novel proteins with enhanced properties, such as increased stability or improved binding affinity, which is vital in biotechnology applications.
  • Research in Cancer Therapeutics: Its application in synthesizing peptides that can inhibit cancer cell growth is a promising area, providing potential pathways for new treatments.

Citations