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Catalog Number:
00083
CAS Number:
66-81-9
Cycloheximide (from Streptomyces griseus)
Purity:
≥ 98% (HPLC)
Synonym(s):
3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin a
Hazmat
Antibiotic
Documents
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Product Information

Cycloheximide, derived from the bacterium Streptomyces griseus, is a potent inhibitor of protein synthesis in eukaryotic cells, making it an invaluable tool in molecular biology and biochemistry research. This compound is widely utilized in studies involving gene expression, cellular signaling, and the effects of various compounds on protein synthesis. Its ability to selectively inhibit the elongation phase of translation allows researchers to dissect the roles of specific proteins in cellular processes, providing insights into mechanisms of action for drugs and potential therapeutic targets.

In addition to its research applications, Cycloheximide has been employed in agricultural settings to study plant responses to stress and pathogen resistance, showcasing its versatility across different scientific fields. The compound's unique properties, including its effectiveness at low concentrations and its ability to penetrate cell membranes, enhance its utility in both laboratory and field studies. Researchers and industry professionals can leverage Cycloheximide to advance their understanding of complex biological systems and develop innovative solutions in health and agriculture.

Synonyms
3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin a
CAS Number
66-81-9
Purity
≥ 98% (HPLC)
Molecular Formula
C15H23NO4
Molecular Weight
281.35
MDL Number
MFCD00082346
PubChem ID
2900
Melting Point
116 - 119 ºC
Appearance
White or off-white crystalline powder
Optical Rotation
[a]D20 = -32 to -26 °
Conditions
Store at 0 - 8 °C
General Information
Synonyms
3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin a
CAS Number
66-81-9
Purity
≥ 98% (HPLC)
Molecular Formula
C15H23NO4
Molecular Weight
281.35
MDL Number
MFCD00082346
PubChem ID
2900
Melting Point
116 - 119 ºC
Appearance
White or off-white crystalline powder
Optical Rotation
[a]D20 = -32 to -26 °
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
Yes
DEA-regulated
No
Warnings
-
Applications

Cycloheximide is widely utilized in research focused on:

  • Protein Synthesis Inhibition: It is primarily used to inhibit protein synthesis in eukaryotic cells, making it a valuable tool for studying cellular processes and the effects of specific proteins in various biological pathways.
  • Cell Biology Studies: Researchers use cycloheximide to investigate the role of specific proteins in cell signaling and metabolism, helping to elucidate mechanisms of diseases, including cancer.
  • Pharmaceutical Development: In drug development, it serves as a model compound to test the efficacy of new therapeutic agents that target protein synthesis, providing insights into potential treatments.
  • Microbiology: It is utilized in microbiological studies to understand the effects of antibiotics on protein synthesis in bacteria, aiding in the discovery of new antimicrobial agents.
  • Neuroscience Research: Cycloheximide is applied in studies of neurodegenerative diseases, allowing scientists to explore the impact of protein synthesis on neuronal health and function.

Citations