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Catalog Number:
00068
CAS Number:
1264-72-8
Colistin sulfate, nonsterile
Purity:
≥ 19000 IU/mg (Assay, dried substance)
Synonym(s):
Polymyxin E sulfate
Antibiotic
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Product Information

Colistin sulfate, nonsterile, is a polypeptide antibiotic that has garnered significant attention in both clinical and agricultural applications. This compound is particularly effective against Gram-negative bacteria, making it a crucial agent in the treatment of infections caused by multidrug-resistant pathogens. Its unique mechanism of action disrupts bacterial cell membrane integrity, leading to cell death, which is vital for researchers and healthcare professionals dealing with challenging infections. In agriculture, colistin sulfate is utilized as a growth promoter in livestock, enhancing feed efficiency and overall animal health, which is essential for sustainable farming practices.

The versatility of colistin sulfate extends to its use in laboratory settings, where it serves as a valuable tool for studying antibiotic resistance mechanisms. Its ability to target specific bacterial strains allows researchers to explore new therapeutic avenues and develop innovative solutions to combat antibiotic resistance. With its proven efficacy and broad applications, colistin sulfate remains a key compound for professionals in healthcare and agriculture, offering both therapeutic benefits and research opportunities.

Synonyms
Polymyxin E sulfate
CAS Number
1264-72-8
Purity
≥ 19000 IU/mg (Assay, dried substance)
Molecular Formula
C53H100N16O13·H2SO4
Molecular Weight
1267.53
MDL Number
MFCD27976775
PubChem ID
73090
Melting Point
200 - 220 ?C (dec.)
Appearance
White to almost white to yellowish powder
Optical Rotation
[a]D20 = -63 to -73 ° (Lit.)
Conditions
Store at 0 - 8 °C
Potency
Potency >19000 u/mg
General Information
Synonyms
Polymyxin E sulfate
CAS Number
1264-72-8
Purity
≥ 19000 IU/mg (Assay, dried substance)
Molecular Formula
C53H100N16O13·H2SO4
Molecular Weight
1267.53
MDL Number
MFCD27976775
PubChem ID
73090
Melting Point
200 - 220 ?C (dec.)
Appearance
White to almost white to yellowish powder
Optical Rotation
[a]D20 = -63 to -73 ° (Lit.)
Conditions
Store at 0 - 8 °C
Potency
Potency >19000 u/mg
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
Yes
DEA-regulated
No
Warnings
-
Applications

Colistin sulfate, nonsterile is widely utilized in research focused on:

  • Antibiotic Development: It plays a crucial role in developing new antibiotics, especially against multidrug-resistant bacteria, helping researchers find effective treatments.
  • Veterinary Medicine: Commonly used in livestock to treat infections, it helps improve animal health and productivity, addressing concerns in the agricultural sector.
  • Microbial Studies: Researchers use it to study the mechanisms of antibiotic resistance in bacteria, providing insights that can lead to better infection control strategies.
  • Pharmaceutical Formulations: It serves as an active ingredient in various formulations, enhancing the efficacy of medications aimed at treating severe bacterial infections.
  • Laboratory Research: Employed in microbiology labs for susceptibility testing, it aids in determining the effectiveness of antibiotics against specific pathogens.

Citations