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Catalog Number:
38281
CAS Number:
58880-19-6
Trichostatine A
Purity:
≥ 98 % (HPLC)
Synonym(s):
TSA, [R-(E,E)]-7-[4-(diméthylamino)phényl]- N -hydroxy-4,6-diméthyl-7-oxo-2,4-heptadiénamide
Documents
$669.40 /10 mg
Taille
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Informations sur le produit

Trichostatin A is a potent histone deacetylase (HDAC) inhibitor that plays a crucial role in epigenetic regulation, making it an invaluable tool in cancer research and therapeutic development. This compound has been shown to induce cell cycle arrest and apoptosis in various cancer cell lines, highlighting its potential as a chemotherapeutic agent. Researchers utilize Trichostatin A to explore mechanisms of gene expression modulation, particularly in studies focused on the reactivation of silenced tumor suppressor genes. Its ability to enhance the efficacy of other anticancer drugs further underscores its significance in combination therapies.

In addition to its applications in oncology, Trichostatin A is also employed in studies of neurodegenerative diseases, where it has demonstrated neuroprotective effects. The compound's unique ability to alter chromatin structure and promote gene expression makes it a valuable asset in the field of epigenetics. With its diverse applications and significant impact on research outcomes, Trichostatin A stands out as a critical reagent for scientists aiming to unravel complex biological processes and develop innovative therapeutic strategies.

Numéro CAS 
58880-19-6
Formule moléculaire
C17H22N2O3
Poids moléculaire 
302.37
Point de fusion 
143 - 145 °C (déc.)
Rotation optique 
135 - 137 ° (C=0,3, MeOH)
Informations générales
Numéro CAS 
58880-19-6
Formule moléculaire
C17H22N2O3
Poids moléculaire 
302.37
Point de fusion 
143 - 145 °C (déc.)
Rotation optique 
135 - 137 ° (C=0,3, MeOH)
Propriétés
Informations complémentaires sur la propriété à venir prochainement !
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Sécurité et réglementation
Matières dangereuses
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Antibiotique
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Réglementé par la DEA
Non
Avertissements 
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Applications

Trichostatin A is widely utilized in research focused on:

  • Epigenetic Research: It is a potent histone deacetylase inhibitor, making it invaluable for studying gene expression and epigenetic modifications in various biological systems.
  • Cancer Therapy Development: Researchers explore its potential in cancer treatments, as it can induce cell cycle arrest and apoptosis in cancer cells, offering insights into novel therapeutic strategies.
  • Neuroscience Studies: The compound is used to investigate neurodegenerative diseases, helping to understand how histone modifications affect neuronal survival and function.
  • Stem Cell Research: Trichostatin A plays a role in enhancing the reprogramming efficiency of somatic cells into induced pluripotent stem cells, which is crucial for regenerative medicine.
  • Antiviral Research: It has shown promise in studies targeting viral infections by modulating host cell pathways, providing a basis for developing antiviral therapies.

Citations