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Catalog Number:
38240
CAS Number:
112887-68-0
Raltitrexed
Purity:
≥ 98 % (HPLC)
Synonym(s):
Acide N -[[5-[[(1,4-dihydro-2-méthyl-4-oxo-6-quinazolinyl)méthyl]méthylamino]-2-thiényl]carbonyl]-L-glutamique, ICI-D-1694
Hazmat
Documents
$334.10 /50 mg
Taille
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Informations sur le produit

Raltitrexed is a potent antifolate compound primarily utilized in the treatment of various cancers, particularly colorectal cancer. As a thymidylate synthase inhibitor, it disrupts DNA synthesis, making it an essential agent in chemotherapy regimens. Its unique mechanism of action allows for effective targeting of rapidly dividing cancer cells, providing a valuable option for oncologists seeking to enhance patient outcomes. Raltitrexed is often favored for its ability to overcome resistance to other chemotherapeutic agents, making it a critical component in combination therapies.

In addition to its primary applications in oncology, Raltitrexed has shown promise in research settings, particularly in studies focused on cellular metabolism and the development of novel therapeutic strategies. Its specific structure allows for targeted modifications, which can lead to the development of new derivatives with improved efficacy and reduced side effects. Researchers and industry professionals can leverage Raltitrexed's unique properties to explore innovative treatment avenues and enhance existing cancer therapies.

Numéro CAS 
112887-68-0
Formule moléculaire
C21H22N4O6S
Poids moléculaire 
458.49
Point de fusion 
176 °C (déc.)
Rotation optique 
[a] D 20 = -15 à -20 ° (C=1 dans MeOH)
Informations générales
Numéro CAS 
112887-68-0
Formule moléculaire
C21H22N4O6S
Poids moléculaire 
458.49
Point de fusion 
176 °C (déc.)
Rotation optique 
[a] D 20 = -15 à -20 ° (C=1 dans MeOH)
Propriétés
Informations complémentaires sur la propriété à venir prochainement !
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Sécurité et réglementation
Matières dangereuses
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Antibiotique
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Réglementé par la DEA
Non
Avertissements 
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Applications

Raltitrexed is widely utilized in research focused on

  • Cancer Treatment: This compound is primarily used as an anti-cancer agent, particularly in the treatment of colorectal cancer. It acts as a thymidylate synthase inhibitor, disrupting DNA synthesis in rapidly dividing cancer cells.
  • Pharmaceutical Development: Raltitrexed serves as a critical reference compound in the development of new anti-cancer drugs. Researchers study its mechanisms to design more effective therapies with fewer side effects.
  • Combination Therapies: It is often used in combination with other chemotherapeutic agents to enhance treatment efficacy. This synergistic approach can improve patient outcomes in various cancer types.
  • Clinical Trials: Raltitrexed is frequently involved in clinical trials aimed at evaluating new treatment regimens. Its established profile helps researchers assess the effectiveness of novel therapeutic strategies.
  • Research on Drug Resistance: Scientists study Raltitrexed to understand mechanisms of drug resistance in cancer cells. Insights gained can lead to the development of strategies to overcome resistance and improve treatment success.

Citations