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Catalog Number:
33598
CAS Number:
1217680-33-5
Fmoc-2-chloro-4-fluoro-D-phénylalanine
Synonym(s):
Fmoc-D-Phe(2-Cl,4-F)-OH, ( Acide R -Fmoc-2-amino-2-chloro-4-fluorophénylpropionique
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$58.39 /100 mg
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Product Information

Fmoc-2-chloro-4-fluoro-D-phenylalanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a unique Fmoc (9-fluorenylmethoxycarbonyl) protecting group, which facilitates the selective protection of the amino group during the synthesis of peptides. Its distinctive chlorofluoro substitution enhances its reactivity, making it an excellent choice for researchers aiming to create complex peptide structures with specific biological activities.

In pharmaceutical research, Fmoc-2-chloro-4-fluoro-D-phenylalanine has been employed in the design of peptide-based therapeutics, particularly in the development of inhibitors and modulators for various biological targets. Its ability to introduce fluorine into peptide sequences can significantly influence the pharmacokinetic properties of the resulting compounds, offering advantages such as increased stability and improved binding affinity. This makes it a valuable tool for medicinal chemists and biochemists looking to innovate in drug design and development.

Synonyms
Fmoc-D-Phe(2-Cl,4-F)-OH, ( Acide R -Fmoc-2-amino-2-chloro-4-fluorophénylpropionique
CAS Number
1217680-33-5
Molecular Formula
C 24 H 19 ClFNO 4
Molecular Weight
439.86
MDL Number
MFCD12198165
PubChem ID
53398086
Conditions
Conserver entre 2 et 8 °C
General Information
Synonyms
Fmoc-D-Phe(2-Cl,4-F)-OH, ( Acide R -Fmoc-2-amino-2-chloro-4-fluorophénylpropionique
CAS Number
1217680-33-5
Molecular Formula
C 24 H 19 ClFNO 4
Molecular Weight
439.86
MDL Number
MFCD12198165
PubChem ID
53398086
Conditions
Conserver entre 2 et 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Non
Antibiotic
Non
DEA-regulated
Non
Warnings
-
Applications

Fmoc-2-chloro-4-fluoro-D-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing for the creation of complex peptide structures with high purity.
  • Drug Development: It is employed in the design of peptide-based drugs, especially those targeting specific receptors, enhancing the efficacy and specificity of therapeutic agents.
  • Bioconjugation: The unique properties of this compound facilitate bioconjugation processes, enabling the attachment of peptides to various biomolecules for targeted drug delivery systems.
  • Research in Neuroscience: Its application in studying neuropeptides helps researchers understand neurological pathways and develop treatments for neurodegenerative diseases.
  • Fluorinated Compound Research: The presence of fluorine in the structure allows for enhanced metabolic stability and bioavailability, making it valuable in the study of fluorinated compounds in medicinal chemistry.

Citations