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Catalog Number:
33597
CAS Number:
1217789-59-7
Fmoc-2-chloro-4-fluoro-L-phénylalanine
Purity:
≥ 98 % (HPLC)
Synonym(s):
Fmoc-L-Phe(2-Cl,4-F)-OH, Acide ( S )-Fmoc-2-amino-2-chloro-4-fluorophénylpropionique, Fmoc-Phe(2-Cl,4-F)-OH
Documents
$50.30 /100 mg
Taille
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Product Information

Fmoc-2-chloro-4-fluoro-L-phenylalanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a unique Fmoc (9-fluorenylmethoxycarbonyl) protecting group, which facilitates the selective modification of amino acids during solid-phase peptide synthesis. Its distinctive chlorofluoro substitution enhances its reactivity and allows for the incorporation of fluorinated residues into peptides, making it an invaluable tool in medicinal chemistry and biochemistry. Researchers appreciate its ability to improve the pharmacokinetic properties of peptides, potentially leading to more effective therapeutic agents.

In addition to its applications in peptide synthesis, Fmoc-2-chloro-4-fluoro-L-phenylalanine is also explored for its role in the development of novel pharmaceuticals targeting various diseases. Its unique structure can contribute to the design of compounds with enhanced bioactivity and selectivity. This compound is particularly relevant for professionals in pharmaceutical research and development, as it opens avenues for creating innovative peptide-based drugs with improved efficacy and safety profiles.

Synonyms
Fmoc-L-Phe(2-Cl,4-F)-OH, Acide ( S )-Fmoc-2-amino-2-chloro-4-fluorophénylpropionique, Fmoc-Phe(2-Cl,4-F)-OH
CAS Number
1217789-59-7
Purity
≥ 98 % (HPLC)
Molecular Formula
C 24 H 19 ClFNO 4
Molecular Weight
439.86
MDL Number
MFCD12198164
PubChem ID
53398086
Appearance
Solide blanc
Optical Rotation
[a] D 25 = -58 ± 1 ° (C = 1 dans DMF)
Conditions
Conserver entre 2 et 8 °C
General Information
Synonyms
Fmoc-L-Phe(2-Cl,4-F)-OH, Acide ( S )-Fmoc-2-amino-2-chloro-4-fluorophénylpropionique, Fmoc-Phe(2-Cl,4-F)-OH
CAS Number
1217789-59-7
Purity
≥ 98 % (HPLC)
Molecular Formula
C 24 H 19 ClFNO 4
Molecular Weight
439.86
MDL Number
MFCD12198164
PubChem ID
53398086
Appearance
Solide blanc
Optical Rotation
[a] D 25 = -58 ± 1 ° (C = 1 dans DMF)
Conditions
Conserver entre 2 et 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Non
Antibiotic
Non
DEA-regulated
Non
Warnings
-
Applications

Fmoc-2-chloro-4-fluoro-L-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the creation of complex peptide sequences with high purity.
  • Drug Development: It plays a significant role in the pharmaceutical industry for developing novel therapeutics, especially in targeting specific biological pathways due to its unique structural properties.
  • Bioconjugation: The chemical is used in bioconjugation techniques, facilitating the attachment of biomolecules to drugs or imaging agents, enhancing their specificity and efficacy in targeted therapies.
  • Research in Neuroscience: It is utilized in studies related to neurotransmitter pathways, helping researchers understand the effects of modified peptides on neuronal activity and behavior.
  • Fluorinated Compounds: The incorporation of fluorine enhances the stability and bioavailability of compounds, making it valuable in the design of fluorinated analogs for various applications in medicinal chemistry.

Citations