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Catalog Number:
23019
CAS Number:
64-86-8
-)-Colchicine
Grade:
Conforme aux spécifications USP
Purity:
94 - 101 % (HPLC)
Hazmat
Documents
$77.82 /1G
Taille
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Informations sur le produit

(-)-Colchicine is a potent alkaloid derived from the plant Colchicum autumnale, commonly known as the autumn crocus. This compound is renowned for its ability to inhibit microtubule polymerization, making it a valuable tool in both research and clinical settings. Its unique mechanism of action allows it to disrupt cell division, which is particularly useful in cancer research and the treatment of gout, where it alleviates inflammation by targeting neutrophil migration. Additionally, (-)-Colchicine has applications in genetic studies, particularly in the field of cytogenetics, where it is used to induce polyploidy in plants, enhancing crop yields and resilience.

Researchers and industry professionals appreciate (-)-Colchicine for its versatility and effectiveness. Its ability to modulate cellular processes makes it a critical compound in drug development and therapeutic applications. Compared to similar compounds, (-)-Colchicine offers a well-characterized profile with established dosage guidelines, ensuring safety and efficacy in its applications. Whether in a laboratory setting or clinical practice, (-)-Colchicine stands out as a reliable choice for those seeking to explore cellular dynamics or manage inflammatory conditions.

Numéro CAS 
64-86-8
Formule moléculaire
C 22 H 256
Poids moléculaire 
399.43
Rotation optique 
[a] D 20 = -240 à -250 º (C=1 dans l'alcool)
Informations générales
Numéro CAS 
64-86-8
Formule moléculaire
C 22 H 256
Poids moléculaire 
399.43
Rotation optique 
[a] D 20 = -240 à -250 º (C=1 dans l'alcool)
Propriétés
Informations complémentaires sur la propriété à venir prochainement !
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Sécurité et réglementation
Matières dangereuses
-
Antibiotique
-
Réglementé par la DEA
Non
Avertissements 
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Applications

(-)-Colchicine is widely utilized in research focused on:

  • Gout Treatment: It is a well-known medication for managing gout attacks by reducing inflammation and pain associated with the condition.
  • Cell Biology: Researchers use colchicine to study cell division, as it disrupts the formation of microtubules, allowing scientists to investigate mitosis and cellular processes.
  • Genetic Research: In plant breeding, colchicine is applied to induce polyploidy, which can lead to the development of new plant varieties with desirable traits.
  • Cancer Research: Its ability to inhibit cell division makes it a valuable tool in cancer research, helping to understand tumor growth and the effects of chemotherapy.
  • Inflammatory Diseases: Colchicine is also being explored for its potential benefits in treating other inflammatory conditions, such as familial Mediterranean fever, showcasing its versatility in therapeutic applications.

Citations