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Catalog Number:
22133
CAS Number:
25316-40-9
Chlorhydrate de doxorubicine
Grade:
Conforme aux spécifications USP
Purity:
98 - 102 % (dosage, sur une base anhydre)
Synonym(s):
Chlorhydrate d'hydroxydaunorubicine, Chlorhydrate d'adriamycine
Documents
$35.00 /25 mg
Taille
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Informations sur le produit

Doxorubicin hydrochloride is a potent anthracycline antibiotic widely utilized in oncology for its effective anti-cancer properties. This compound is primarily used in the treatment of various cancers, including breast cancer, bladder cancer, and leukemia, owing to its ability to intercalate DNA and inhibit topoisomerase II, leading to apoptosis in rapidly dividing cells. Its unique structure allows for enhanced cellular uptake, making it a critical component in combination chemotherapy regimens.

In addition to its therapeutic applications, Doxorubicin hydrochloride is also being explored in research settings for its potential in targeted drug delivery systems and nanomedicine, where its cytotoxic effects can be harnessed in a more controlled manner. The compound's versatility and effectiveness make it a valuable asset in both clinical and research environments, providing significant benefits in cancer treatment protocols and innovative therapeutic strategies.

Numéro CAS 
25316-40-9
Formule moléculaire
C27H29NO11 · HCl
Poids moléculaire 
579.98
Rotation optique 
[a]D20 = 240 - 290 °
Informations générales
Numéro CAS 
25316-40-9
Formule moléculaire
C27H29NO11 · HCl
Poids moléculaire 
579.98
Rotation optique 
[a]D20 = 240 - 290 °
Propriétés
Informations complémentaires sur la propriété à venir prochainement !
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Sécurité et réglementation
Matières dangereuses
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Antibiotique
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Réglementé par la DEA
Non
Avertissements 
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Applications

Doxorubicin hydrochloride is widely utilized in research focused on

  • Cancer Treatment: This compound is a cornerstone in chemotherapy regimens for various cancers, including breast, lung, and leukemia. Its ability to intercalate DNA helps inhibit cancer cell growth effectively.
  • Combination Therapies: It is often used in combination with other anticancer drugs to enhance therapeutic efficacy and reduce the likelihood of drug resistance, providing a more comprehensive treatment approach.
  • Research in Drug Development: Doxorubicin hydrochloride serves as a model compound in the development of new anticancer agents, allowing researchers to study mechanisms of action and improve drug formulations.
  • Targeted Drug Delivery Systems: Researchers are exploring its use in nanotechnology, where it can be encapsulated in nanoparticles for targeted delivery, minimizing side effects and maximizing drug concentration at tumor sites.
  • Cardiotoxicity Studies: Due to its known side effects, it is frequently used in studies aimed at understanding and mitigating cardiotoxicity, helping to develop safer treatment protocols for patients.

Citations