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Catalog Number:
16538
CAS Number:
203866-15-3
Boc-4,4-Difluoro-L-proline
Purity:
≥ 98 % (HPLC)
Synonym(s):
Acide (2 S -1-( tert -Butoxycarbonyl)-4,4-difluoropyrrolidine-2-carboxylique
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Product Information

Boc-4,4-Difluoro-L-proline is a specialized amino acid derivative that plays a crucial role in peptide synthesis and medicinal chemistry. This compound is recognized for its unique difluoromethyl group, which enhances the stability and bioactivity of peptides, making it an invaluable tool in drug development. Researchers utilize Boc-4,4-Difluoro-L-proline to create fluorinated peptides that exhibit improved pharmacological properties, such as increased metabolic stability and enhanced binding affinity to biological targets. Its application extends to the design of inhibitors and modulators in various therapeutic areas, including oncology and neurology.

The compound's ability to incorporate fluorine into peptide structures allows for the exploration of novel therapeutic pathways, providing a competitive edge in the development of next-generation pharmaceuticals. Additionally, Boc-4,4-Difluoro-L-proline is compatible with standard peptide coupling techniques, making it an accessible choice for researchers aiming to innovate in peptide-based therapies. Its unique properties and practical applications position it as a vital component in the toolkit of chemists and pharmaceutical scientists.

Synonyms
Acide (2 S -1-( tert -Butoxycarbonyl)-4,4-difluoropyrrolidine-2-carboxylique
CAS Number
203866-15-3
Purity
≥ 98 % (HPLC)
Molecular Formula
C 10 H 15 F 2 NON 4
Molecular Weight
251.23
MDL Number
MFCD03094917
PubChem ID
23512514
Melting Point
118 - 123 °C
Appearance
Solide blanc
Optical Rotation
[α] D 25 = -44 ± 2º (C = 1,04 g/100 ml dans MeOH)
Conditions
Conserver à 0-8°C
General Information
Synonyms
Acide (2 S -1-( tert -Butoxycarbonyl)-4,4-difluoropyrrolidine-2-carboxylique
CAS Number
203866-15-3
Purity
≥ 98 % (HPLC)
Molecular Formula
C 10 H 15 F 2 NON 4
Molecular Weight
251.23
MDL Number
MFCD03094917
PubChem ID
23512514
Melting Point
118 - 123 °C
Appearance
Solide blanc
Optical Rotation
[α] D 25 = -44 ± 2º (C = 1,04 g/100 ml dans MeOH)
Conditions
Conserver à 0-8°C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Non
Antibiotic
Non
DEA-regulated
Non
Warnings
-
Applications

Boc-4,4-Difluoro-L-proline is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a valuable building block in the synthesis of peptides, particularly in the development of peptide-based drugs. Its unique fluorine substituents can enhance the stability and bioactivity of the resulting peptides.
  • Drug Development: The incorporation of Boc-4,4-Difluoro-L-proline in drug design can lead to compounds with improved pharmacological properties, making it a key player in pharmaceutical research.
  • Biochemical Studies: Researchers use this chemical to study protein folding and interactions, as its structural properties can mimic natural amino acids while providing distinct characteristics for analysis.
  • Material Science: In the field of materials, this compound can be utilized in the development of polymers and coatings that require specific mechanical and thermal properties, benefiting industries such as electronics and automotive.
  • Fluorinated Compounds Research: Its unique fluorinated structure allows for exploration in the synthesis of new fluorinated compounds, which are essential in various applications including agrochemicals and specialty chemicals.

Citations