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Catalog Number:
05306
CAS Number:
133367-33-6
N α - Fmoc- N im -méthoxytrityl-L-histidine
Purity:
≥ 99 % (HPLC)
Synonym(s):
Fmoc-L-His(Mmt)-OH
Documents
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Informations sur le produit

Na-Fmoc-Nim-methoxytrityl-L-histidine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (fluorenylmethyloxycarbonyl) group, which allows for selective deprotection during the synthesis process, making it an essential building block for creating complex peptides. Its methoxytrityl group enhances stability and solubility, facilitating its application in various organic synthesis reactions. Researchers and industry professionals appreciate its role in the development of peptide-based therapeutics, particularly in the fields of oncology and immunology, where precise peptide sequences are crucial for efficacy.

The unique combination of protective groups in Na-Fmoc-Nim-methoxytrityl-L-histidine not only streamlines the synthesis process but also improves the yield and purity of the final products. This compound is particularly advantageous for those working on the synthesis of cyclic peptides or peptide libraries, where efficiency and precision are paramount. Its ability to withstand harsh reaction conditions while maintaining structural integrity makes it a preferred choice among chemists and pharmaceutical developers.

Numéro CAS 
133367-33-6
Formule moléculaire
C41H35N3O5
Poids moléculaire 
649.7
Point de fusion 
142-152 ?C
Rotation optique 
[α] D 20 = 25 ± 3º (C=1, en THF)
Informations générales
Numéro CAS 
133367-33-6
Formule moléculaire
C41H35N3O5
Poids moléculaire 
649.7
Point de fusion 
142-152 ?C
Rotation optique 
[α] D 20 = 25 ± 3º (C=1, en THF)
Propriétés
Informations complémentaires sur la propriété à venir prochainement !
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Sécurité et réglementation
Matières dangereuses
-
Antibiotique
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Réglementé par la DEA
Non
Avertissements 
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Applications

Na-Fmoc-Nim-methoxytrityl-L-histidine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in solid-phase peptide synthesis, enabling the creation of complex peptides with high purity and yield.
  • Drug Development: It is used in the design of peptide-based therapeutics, particularly in oncology and immunology, where specific targeting of cancer cells is crucial.
  • Bioconjugation: The chemical facilitates the attachment of peptides to various biomolecules, enhancing the efficacy of drug delivery systems and diagnostics.
  • Research in Protein Engineering: It aids in the modification of histidine residues in proteins, allowing researchers to study protein function and interactions more effectively.
  • Analytical Chemistry: The compound is employed in the development of analytical methods for detecting and quantifying peptides in biological samples, providing valuable insights into metabolic processes.

Citations