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Catalog Number:
04142
CAS Number:
114873-11-9
Boc-3-fluoro-D-phénylalanine
Purity:
≥ 98 % (HPLC)
Synonym(s):
Boc-D-Phe(3-F)-OH, Boc- m -Fluoro-D-Phe-OH, ( Acide R -2-Boc-amino-3-(3-fluorophényl)propionique
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Product Information

Boc-3-fluoro-D-phenylalanine is a valuable amino acid derivative widely utilized in peptide synthesis and medicinal chemistry. This compound features a unique fluorine substitution that enhances its biological activity, making it an essential building block for the development of novel therapeutics. Its Boc (tert-butyloxycarbonyl) protecting group allows for selective deprotection, facilitating the incorporation of this amino acid into complex peptide structures. Researchers have successfully employed Boc-3-fluoro-D-phenylalanine in the design of peptide-based drugs, particularly in the fields of oncology and neurology, where precise modifications can significantly influence pharmacological properties.

The compound's distinct properties, such as its ability to mimic natural amino acids while providing additional functional benefits, make it a preferred choice for scientists aiming to create more effective and targeted therapies. Its application in structure-activity relationship (SAR) studies enables researchers to explore the effects of fluorination on peptide stability and activity, ultimately leading to the discovery of innovative drug candidates. With its promising potential in drug development, Boc-3-fluoro-D-phenylalanine stands out as a critical tool for advancing pharmaceutical research.

Synonyms
Boc-D-Phe(3-F)-OH, Boc- m -Fluoro-D-Phe-OH, ( Acide R -2-Boc-amino-3-(3-fluorophényl)propionique
CAS Number
114873-11-9
Purity
≥ 98 % (HPLC)
Molecular Formula
C 14 H 18 FNO 4
Molecular Weight
283.2
MDL Number
MFCD00672523
PubChem ID
3698526
Melting Point
75 - 80 ?C
Appearance
Poudre cristalline blanc cassé
Optical Rotation
[a] 20 D = -22 ± 2 º (C=1 dans EtOH)
Conditions
Conserver à 0 - 8 °C
General Information
Synonyms
Boc-D-Phe(3-F)-OH, Boc- m -Fluoro-D-Phe-OH, ( Acide R -2-Boc-amino-3-(3-fluorophényl)propionique
CAS Number
114873-11-9
Purity
≥ 98 % (HPLC)
Molecular Formula
C 14 H 18 FNO 4
Molecular Weight
283.2
MDL Number
MFCD00672523
PubChem ID
3698526
Melting Point
75 - 80 ?C
Appearance
Poudre cristalline blanc cassé
Optical Rotation
[a] 20 D = -22 ± 2 º (C=1 dans EtOH)
Conditions
Conserver à 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Non
Antibiotic
Non
DEA-regulated
Non
Warnings
-
Applications

Boc-3-fluoro-D-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a valuable building block in the synthesis of peptides, particularly in creating fluorinated amino acids that can enhance the stability and activity of therapeutic peptides.
  • Drug Development: Its unique fluorine substitution allows researchers to explore new drug candidates with improved pharmacological properties, making it essential in medicinal chemistry.
  • Biochemical Research: Used in studies involving protein folding and interactions, it helps in understanding how modifications affect protein behavior, which is crucial for developing targeted therapies.
  • Diagnostics: The incorporation of this compound into biomolecules can improve imaging techniques, aiding in the diagnosis of diseases through enhanced contrast in imaging studies.
  • Material Science: Its properties can be leveraged in the development of new materials with specific functionalities, such as improved biocompatibility for biomedical applications.

Citations