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Catalog Number:
04116
CAS Number:
177966-59-5
Fmoc-3,4-dichloro-L-phénylalanine
Purity:
≥ 98 % (HPLC)
Synonym(s):
Fmoc-L-Phe(3,4-DiCl)-OH, Fmoc-L-Phe(3,4- Cl2 )-OH, Fmoc-Phe(3,4-DiCl)-OH
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Product Information

Fmoc-3,4-dichloro-L-phenylalanine is a valuable amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is crucial for the selective protection of amino groups during solid-phase peptide synthesis. Its unique structure, characterized by the presence of two chlorine atoms on the phenyl ring, enhances its reactivity and allows for the introduction of diverse functionalities in peptide chains. Researchers and industry professionals appreciate its role in creating complex peptides with improved stability and bioactivity, making it an essential tool in medicinal chemistry and biochemistry.

This compound is particularly beneficial in the synthesis of peptide-based therapeutics, where precision and control over the amino acid sequence are paramount. Its application extends to the development of inhibitors, vaccines, and other biologically active compounds. By incorporating Fmoc-3,4-dichloro-L-phenylalanine into their workflows, scientists can achieve higher yields and purities in their peptide products, ultimately leading to more effective research outcomes and therapeutic solutions.

Synonyms
Fmoc-L-Phe(3,4-DiCl)-OH, Fmoc-L-Phe(3,4- Cl2 )-OH, Fmoc-Phe(3,4-DiCl)-OH
CAS Number
177966-59-5
Purity
≥ 98 % (HPLC)
Molecular Formula
C 24 H 19 Cl 2 NO 4
Molecular Weight
456.4
MDL Number
MFCD00273473
PubChem ID
3365122
Melting Point
112-120 ºC
Appearance
Solide blanc à blanc cassé
Optical Rotation
[a] D 20
Conditions
Conserver à 0-8 °C
General Information
Synonyms
Fmoc-L-Phe(3,4-DiCl)-OH, Fmoc-L-Phe(3,4- Cl2 )-OH, Fmoc-Phe(3,4-DiCl)-OH
CAS Number
177966-59-5
Purity
≥ 98 % (HPLC)
Molecular Formula
C 24 H 19 Cl 2 NO 4
Molecular Weight
456.4
MDL Number
MFCD00273473
PubChem ID
3365122
Melting Point
112-120 ºC
Appearance
Solide blanc à blanc cassé
Optical Rotation
[a] D 20
Conditions
Conserver à 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Non
Antibiotic
Non
DEA-regulated
Non
Warnings
-
Applications

Fmoc-3,4-dichloro-L-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound is commonly used as a building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS). Its protective Fmoc group allows for selective deprotection, facilitating the assembly of complex peptide chains.
  • Drug Development: Researchers leverage its unique structure to design and develop new pharmaceuticals, especially in the field of cancer research, where modifications can lead to more effective treatments.
  • Bioconjugation: The compound can be employed in bioconjugation techniques, enabling the attachment of peptides to various biomolecules, which is essential for creating targeted drug delivery systems.
  • Protein Engineering: It plays a significant role in protein engineering, allowing scientists to introduce specific modifications to proteins, enhancing their stability and functionality for therapeutic applications.
  • Analytical Chemistry: Fmoc-3,4-dichloro-L-phenylalanine is also used in analytical methods to study protein interactions and conformational changes, providing insights into protein behavior in biological systems.

Citations