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Catalog Number:
01786
CAS Number:
51-21-8
5-Fluorouracile
Grade:
Conforme aux spécifications USP
Purity:
98 - 102 % (dosage sur une base sèche)
Synonym(s):
2,4-Dihydroxy-5-fluoropyrimidine, 5-Fluoro-1 H -pyrimidine-2,4-dione
Hazmat
Documents
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Product Information

5-Fluorouracil is a potent antimetabolite and a fluorinated pyrimidine analog widely utilized in the treatment of various cancers, particularly colorectal, breast, and head and neck cancers. This compound functions by inhibiting thymidylate synthase, a crucial enzyme in DNA synthesis, thereby disrupting the proliferation of cancer cells. Its effectiveness is enhanced when combined with other chemotherapeutic agents, making it a cornerstone in combination therapy regimens. Researchers also explore its potential in topical formulations for skin cancers, showcasing its versatility in oncology.

In addition to its therapeutic applications, 5-Fluorouracil is valuable in research settings, particularly in studies focused on cancer biology and drug resistance mechanisms. Its unique properties allow for the development of targeted delivery systems, improving the efficacy and reducing the side effects of chemotherapy. With ongoing advancements in formulation technologies, 5-Fluorouracil continues to hold promise for enhancing patient outcomes in cancer treatment.

Synonyms
2,4-Dihydroxy-5-fluoropyrimidine, 5-Fluoro-1 H -pyrimidine-2,4-dione
CAS Number
51-21-8
Purity
98 - 102 % (dosage sur une base sèche)
Grade
Conforme aux spécifications USP
Molecular Formula
C4H3N2O2F
Molecular Weight
130.1
MDL Number
MFCD00006018
PubChem ID
3385
Appearance
Poudre cristalline blanche
Conditions
Magasin chez RT
General Information
Synonyms
2,4-Dihydroxy-5-fluoropyrimidine, 5-Fluoro-1 H -pyrimidine-2,4-dione
CAS Number
51-21-8
Purity
98 - 102 % (dosage sur une base sèche)
Grade
Conforme aux spécifications USP
Molecular Formula
C4H3N2O2F
Molecular Weight
130.1
MDL Number
MFCD00006018
PubChem ID
3385
Appearance
Poudre cristalline blanche
Conditions
Magasin chez RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Oui
Antibiotic
Non
DEA-regulated
Non
Warnings
-
Applications

5-Fluorouracil is widely utilized in research focused on

  • Cancer Treatment: This compound is a key chemotherapeutic agent used to treat various types of cancer, including colorectal and breast cancer. It works by inhibiting DNA synthesis, which helps to slow down or stop the growth of cancer cells.
  • Topical Applications: In dermatology, it is used in topical formulations to treat skin cancers and precancerous conditions like actinic keratosis. Its localized application minimizes systemic side effects.
  • Research in Molecular Biology: 5-Fluorouracil is often employed in laboratory settings to study cellular responses to DNA damage and repair mechanisms, providing insights into cancer biology.
  • Combination Therapies: It is frequently used in combination with other chemotherapeutic agents to enhance treatment efficacy, allowing for tailored cancer treatment plans that can improve patient outcomes.
  • Pharmaceutical Development: The compound serves as a model for developing new drugs targeting similar pathways, aiding pharmaceutical researchers in designing more effective cancer therapies.

Citations