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Catalog Number:
01491
CAS Number:
154-42-7
6-Thioguanine
Purity:
≥ 98 % (HPLC)
Synonym(s):
2-Amino-6-mercaptopurine, 2-Amino-1,7(9)-dihydro-purine-6-thione
Hazmat
Documents
$22.03 /1G
Taille
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Informations sur le produit

6-Thioguanine is a potent purine analog that plays a crucial role in the field of medicinal chemistry, particularly in the treatment of certain types of cancer and autoimmune diseases. This compound is recognized for its ability to inhibit DNA synthesis, making it a valuable therapeutic agent in chemotherapy regimens for acute lymphoblastic leukemia and other malignancies. Its unique thiol group enhances its reactivity and bioavailability, allowing for effective incorporation into nucleic acids, which is essential for its mechanism of action.

In addition to its applications in oncology, 6-Thioguanine is also utilized in research settings to study purine metabolism and the effects of thiopurine drugs on cellular processes. Its ability to modulate immune responses makes it a candidate for treating conditions like inflammatory bowel disease. Researchers appreciate its specificity and efficacy, which can lead to improved patient outcomes compared to other purine analogs. With ongoing studies exploring its potential in combination therapies, 6-Thioguanine remains a compound of significant interest in both clinical and research environments.

Numéro CAS 
154-42-7
Formule moléculaire
C5H5N5S
Poids moléculaire 
167.2
Point de fusion 
≥ 300 °C
Informations générales
Numéro CAS 
154-42-7
Formule moléculaire
C5H5N5S
Poids moléculaire 
167.2
Point de fusion 
≥ 300 °C
Propriétés
Informations complémentaires sur la propriété à venir prochainement !
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Sécurité et réglementation
Matières dangereuses
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Antibiotique
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Réglementé par la DEA
Non
Avertissements 
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Applications

6-Thioguanine is widely utilized in research focused on:

  • Cancer Treatment: This compound is primarily used in chemotherapy for treating certain types of leukemia and other cancers, offering an alternative to traditional therapies.
  • Immunosuppressive Therapy: It plays a crucial role in managing autoimmune diseases and preventing organ transplant rejection by suppressing the immune response.
  • Genetic Research: Researchers use 6-Thioguanine to study genetic mutations and their effects on cellular processes, providing insights into disease mechanisms.
  • Pharmaceutical Development: The compound is a key ingredient in developing new drugs, particularly for conditions that require targeted therapy, enhancing treatment efficacy.
  • Biochemical Studies: It serves as a tool in various biochemical assays, helping scientists understand metabolic pathways and enzyme functions.

Citations