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Catalog Number:
01355
CAS Number:
17791-52-5
Boc-L-histidine
Purity:
≥ 99,5 % (HPLC chirale, HPLC)
Synonym(s):
Boc-L-His-OH
Documents
$18.53 /1G
Taille
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Informations sur le produit

Boc-L-histidine is a valuable amino acid derivative widely utilized in peptide synthesis and pharmaceutical research. This compound features a tert-butyloxycarbonyl (Boc) protecting group, which enhances its stability and solubility, making it an ideal choice for the synthesis of complex peptides. Its unique imidazole side chain not only contributes to its biochemical properties but also plays a crucial role in various enzymatic reactions and protein interactions. Researchers often leverage Boc-L-histidine in the development of peptide-based drugs, particularly in the fields of oncology and immunology, where precise modifications can lead to improved therapeutic efficacy.

In addition to its applications in drug development, Boc-L-histidine is also employed in the synthesis of bioconjugates and as a building block for the preparation of histidine-containing peptides. Its ability to facilitate the formation of stable peptide bonds while maintaining the integrity of the histidine residue makes it a preferred choice among chemists and biochemists. With its versatile applications and significant role in advancing peptide chemistry, Boc-L-histidine stands out as a crucial compound for researchers aiming to innovate in the pharmaceutical and biotechnological sectors.

Numéro CAS 
17791-52-5
Formule moléculaire
C11H17N3O4
Poids moléculaire 
255.29
Point de fusion 
190 - 198 ?C
Rotation optique 
[a] 20 D = 25 ± 2 ° (C=1 dans MeOH)
Informations générales
Numéro CAS 
17791-52-5
Formule moléculaire
C11H17N3O4
Poids moléculaire 
255.29
Point de fusion 
190 - 198 ?C
Rotation optique 
[a] 20 D = 25 ± 2 ° (C=1 dans MeOH)
Propriétés
Informations complémentaires sur la propriété à venir prochainement !
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Sécurité et réglementation
Matières dangereuses
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Antibiotique
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Réglementé par la DEA
Non
Avertissements 
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Applications

Boc-L-histidine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly those that require histidine residues for biological activity. Its protective Boc group allows for selective reactions, enhancing the efficiency of peptide assembly.
  • Drug Development: In pharmaceutical research, Boc-L-histidine is used to create histidine-containing compounds that can act as potential drug candidates, especially in the development of treatments for conditions like cancer and metabolic disorders.
  • Bioconjugation: The compound is valuable in bioconjugation processes, where it can be attached to biomolecules such as antibodies or enzymes, improving their stability and functionality for diagnostic and therapeutic applications.
  • Protein Engineering: Researchers utilize Boc-L-histidine in the design of modified proteins that require specific histidine interactions, which can enhance enzyme activity or alter binding properties in various industrial applications.
  • Analytical Chemistry: It is also employed in analytical methods, such as chromatography, to help separate and identify histidine derivatives, providing insights into protein structure and function.

Citations