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Catalog Number:
38363
CAS Number:
19545-26-7
Wortmannin
Purity:
≥ 98 % (HPLC)
Synonym(s):
KY 12420
Hazmat
Documents
$294.24 /20 mg
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Product Information

Wortmannin is a potent and selective inhibitor of phosphoinositide 3-kinases (PI3Ks), making it an invaluable tool in biomedical research, particularly in cancer studies and cellular signaling pathways. This compound is recognized for its ability to induce apoptosis in various cancer cell lines, thereby providing insights into therapeutic strategies targeting PI3K pathways. Its unique structure, featuring multiple functional groups, enhances its reactivity and specificity, allowing researchers to explore its effects on cellular processes with precision.

In addition to its applications in cancer research, Wortmannin has been utilized in studies investigating insulin signaling and the regulation of glucose metabolism. Its role in modulating cellular responses to growth factors and hormones positions it as a critical compound for understanding metabolic disorders. Researchers appreciate Wortmannin for its ability to provide clarity in complex signaling networks, making it a preferred choice for those looking to delve deeper into the mechanisms of cell growth and survival.

Synonyms
KY 12420
CAS Number
19545-26-7
Purity
≥ 98 % (HPLC)
Molecular Formula
C23H24O8
Molecular Weight
428.44
MDL Number
MFCD00133927
PubChem ID
5691
Melting Point
235 - 239 °C
Appearance
Poudre blanche à jaune à cristal
Optical Rotation
85 - 89 ° (C=0,17, CHCl3)
Conditions
Conserver à < -20 °C
General Information
Synonyms
KY 12420
CAS Number
19545-26-7
Purity
≥ 98 % (HPLC)
Molecular Formula
C23H24O8
Molecular Weight
428.44
MDL Number
MFCD00133927
PubChem ID
5691
Melting Point
235 - 239 °C
Appearance
Poudre blanche à jaune à cristal
Optical Rotation
85 - 89 ° (C=0,17, CHCl3)
Conditions
Conserver à < -20 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Oui
Antibiotic
Non
DEA-regulated
Non
Warnings
-
Applications

Wortmannin is widely utilized in research focused on various applications:

  • Cancer Research: This compound is a potent inhibitor of phosphoinositide 3-kinase (PI3K), making it valuable in studying cancer cell signaling pathways. Researchers use it to explore potential treatments for various cancers by understanding how PI3K inhibition affects tumor growth.
  • Neuroscience: Wortmannin is employed to investigate the role of PI3K in neuronal survival and differentiation. Its application helps in understanding neurodegenerative diseases and developing neuroprotective strategies.
  • Cardiovascular Studies: By inhibiting PI3K, this compound aids in exploring its effects on cardiac function and signaling pathways, which can lead to new insights into heart diseases and potential therapeutic targets.
  • Immunology: Researchers utilize wortmannin to study immune cell signaling and function. Its ability to modulate immune responses makes it a useful tool in developing treatments for autoimmune diseases.
  • Drug Development: As a research tool, wortmannin helps in the screening of new drug candidates targeting PI3K pathways. Its specificity allows scientists to better understand the mechanisms of action of potential therapeutics.

Citations