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Catalog Number:
04817
CAS Number:
109425-51-6
Fmoc-L-histidine(2-chlorotrityl resin)amide
Synonym(s):
Fmoc-L-His(trityl resin)-NH2
Documents
$127.79 /1G
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Product Information

Fmoc-L-histidine(2-chlorotrityl resin)amide is a highly versatile compound widely utilized in peptide synthesis and drug development. This protected amino acid derivative features a fluorenylmethoxycarbonyl (Fmoc) group, which provides stability during the synthesis process while allowing for easy removal under mild conditions. Its unique structure, which includes a trityl-imidazole moiety, enhances its reactivity and compatibility with various coupling agents, making it an ideal choice for researchers focused on developing complex peptides and proteins.

This compound is particularly beneficial in the pharmaceutical industry, where it serves as a building block for the synthesis of bioactive peptides, including those used in therapeutic applications. Its ability to facilitate the formation of peptide bonds while maintaining the integrity of sensitive functional groups makes it a preferred choice among chemists. Additionally, Fmoc-L-histidine(2-chlorotrityl resin)amide's compatibility with automated synthesizers streamlines the peptide synthesis process, improving efficiency and yield.

Synonyms
Fmoc-L-His(trityl resin)-NH2
CAS Number
109425-51-6
MDL Number
MFCD00043332
PubChem ID
4072357
Substitution
0.2-0.6 meq/g
Mesh Size
200-400 mesh
Conditions
Store at 0-8 °C
%DVB
1% DVB
General Information
Synonyms
Fmoc-L-His(trityl resin)-NH2
CAS Number
109425-51-6
MDL Number
MFCD00043332
PubChem ID
4072357
Substitution
0.2-0.6 meq/g
Mesh Size
200-400 mesh
Conditions
Store at 0-8 °C
%DVB
1% DVB
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-histidine(2-chlorotrityl resin)amide is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in solid-phase peptide synthesis, allowing researchers to create complex peptides efficiently. Its protective Fmoc group facilitates easy deprotection, making it ideal for sequential synthesis.
  • Drug Development: In pharmaceutical research, it is used to develop peptide-based drugs. Its unique structure can enhance the stability and bioavailability of therapeutic peptides, which is crucial for effective treatment.
  • Bioconjugation: The resin can be used in bioconjugation processes, where it helps attach peptides to other molecules, such as antibodies or drugs, improving targeted delivery systems in cancer therapy.
  • Protein Engineering: Researchers utilize this compound to modify histidine residues in proteins, enabling the study of protein interactions and functions, which is essential in understanding biological processes.
  • Analytical Chemistry: It plays a role in the development of analytical methods for detecting and quantifying peptides, aiding in quality control and research applications in various industries.

Citations