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Catalog Number:
38471
CAS Number:
50-76-0
Actinomycin D from Streptomyces species
Grade:
suitable for cell culture
Purity:
≥ 95% (HPLC)
Synonym(s):
Dactinomycin, Actinomycin C1
Hazmat
Documents
$38.46 /5MG
Pack Size Availability Price
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Product Information

Actinomycin D is a potent antibiotic derived from Streptomyces species, renowned for its significant role in cancer research and treatment. This compound exhibits remarkable antitumor activity by intercalating into DNA, thereby inhibiting RNA synthesis. Its unique mechanism of action makes it invaluable in the development of chemotherapeutic agents, particularly in the treatment of various cancers, including Wilms' tumor and rhabdomyosarcoma. Researchers appreciate Actinomycin D not only for its efficacy but also for its ability to serve as a tool in molecular biology studies, such as gene expression analysis and the investigation of cellular processes.

In addition to its applications in oncology, Actinomycin D is utilized in laboratory settings to explore the effects of transcriptional inhibition on cell growth and differentiation. Its ability to disrupt the transcription process allows scientists to gain insights into gene regulation and cellular responses to stress. With its proven track record and diverse applications, Actinomycin D remains a critical compound for both clinical and research purposes, offering significant benefits in understanding and combating cancer.

Synonyms
Dactinomycin, Actinomycin C1
CAS Number
50-76-0
Purity
≥ 95% (HPLC)
Grade
suitable for cell culture
Molecular Formula
C62H86N12O16
Molecular Weight
1255.42
MDL Number
MFCD00005033
PubChem ID
2019
Melting Point
243 - 248 °C
Appearance
Bright red crystalline powder
Optical Rotation
[a]20D = -292 to -317 °
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Dactinomycin, Actinomycin C1
CAS Number
50-76-0
Purity
≥ 95% (HPLC)
Grade
suitable for cell culture
Molecular Formula
C62H86N12O16
Molecular Weight
1255.42
MDL Number
MFCD00005033
PubChem ID
2019
Melting Point
243 - 248 °C
Appearance
Bright red crystalline powder
Optical Rotation
[a]20D = -292 to -317 °
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Actinomycin D from Streptomyces species is widely utilized in research focused on:

  • Cancer Treatment: This compound is a potent anti-cancer agent, commonly used in chemotherapy regimens for various types of tumors, including Wilms' tumor and rhabdomyosarcoma, providing effective treatment options for patients.
  • Gene Expression Studies: Researchers employ Actinomycin D to inhibit RNA synthesis, allowing them to study gene expression and regulation mechanisms in cellular biology, which is crucial for understanding diseases.
  • Antibiotic Development: Its unique structure and mechanism of action inspire the development of new antibiotics, making it a valuable compound in the fight against antibiotic-resistant bacteria.
  • Cell Cycle Research: Actinomycin D is used to investigate the effects of transcriptional inhibition on cell cycle progression, helping scientists understand cellular responses to stress and potential therapeutic targets.
  • Biotechnology Applications: In biomanufacturing, it serves as a tool for optimizing the production of recombinant proteins by controlling gene expression, enhancing yield and efficiency in industrial processes.

Citations