A New Way to Screen
Built by BRiTeCycle®, a synthesis platform developed by BRT Biotechnologies, these MCP libraries allow for more rapid early-stage drug discovery, particularly hard-to-drug targets.
We offer extensive chemical diversity, flexible formats, rapid analog follow-up, and ready-to-screen usability, providing researchers with a new way to screen, helping streamline workflows wherever you are in your process, and accelerate the path from hit identification to lead optimization.
About the Libraries
All libraries are made-to-order to ensure they meet your specific requirements, and are ready for immediate use.
Key Features:
- Synthesized from 1,000's of unique α-, β-, and γ-amino acid building blocks available at early stage discovery and hit-to-lead expansion
- Compatible with phenotypic and mass spec-based assays
- No tags or barcodes for easy functional screens, as well as affinity-based selections
- Microgram scale syntheses giving you just what you need, when you need it
Customizable Formats:
- Sizes: 384 - 10,000+ MCPs
- Delivery: discrete compounds (dried or in DMSO) or deconvolutable pools, in 384-well plates
- Custom plating and barcoding upon request
- Custom analog libraries
Rapid Turnaround Times: Get your Hypotheses Tested Quickly
- 384 compound library: 1-2 weeks (approx.)
- 2,300 compound library: 3-4 weeks (approx.)
Accessible Pricing for Every Stage of Discovery:
- Custom library pricing ranges from $30–$100/MCP*, with costs dropping as your library size scales. Whether you're running an early exploratory screen or a full hit-to-lead campaign, BRiTeCycle® libraries are designed to deliver exceptional value without compromising on quality or diversity
*Pricing based on a typical 12-mer MCP with head-to-tail cyclization.
Support:
- 30+ years of peptide chemistry experience
- Resynthesis of up to 24 MCPs at a larger scale
- Hit-to-lead expansion through custom follow-up libraries
What’s BRiTeCycle®?
Developed by a team of BRT scientists with deep expertise in discovery chemistry, BRiTeCycle® is a proprietary synthesis engine enabling structurally diverse, non-canonical macrocyclic peptides.
Despite its recent introduction, the platform has already demonstrated significant impact:
- Enabling 10x larger libraries
- 4x faster iteration cycles
- 10,000 macrocycles synthesized, delivered, and screened by NIH/NCATS
What Makes BRiTeCycle® MCP Libraries Special?
Support for Your Current Stage
Support for Your Current Stage
Choose from 1,000’s of building blocks at early stage discovery and hit-to-lead expansion.
No Tags or Barcodes
No Tags or Barcodes
For easy functional screens, as well as affinity-based selections.
Powerful Diversity
Powerful Diversity
Explore 2,300 or 10,000+ macrocyclic hexapeptides synthesized from collections of 60+ unique α-, β-, and γ-amino acid building blocks—including N-alkylated and cyclic structures - out of the 1,000's that are commercially available.
Ready for Real Screens
Ready for Real Screens
Optimized for both phenotypic assays and mass spec-based workflows, these libraries give you the depth and selectivity to uncover novel hits—even in complex biological systems.
Flexible Formats
Flexible Formats
Choose between discrete compounds (dried or in DMSO) or deconvolutable pools. All available to deliver in 384-well plates.
Support
Support
- Resynthesis of hit MCPs
- Peptide expertise provided throughout the process
Get Started
- Request a quote online. Request here.
- Book an online consultation with our scientific team to tailor the library to your assay and screening needs. Book here.
- Submit an order via PO and make a payment.
- Receive your made-to-order library in as little as 3 weeks.
Frequently Asked Questions
Who can purchase these MCP libraries?
Who can purchase these MCP libraries?
Only customers located within the United States and Canada can purchase these libraries.
What is BRT Technologies (BRT)?
What is BRT Technologies (BRT)?
BRT Biotechnologies was founded by Jane Liu, Gregory Copeland and a team of expert scientists with the vision of advancing drug discovery by providing high quality macrocycle libraries that enable rapid identification of promising drug leads. Leveraging decades of expertise in medicinal chemistry, BRT developed the innovative BRiTeCycle® platform.
What makes these MCP libraries different?
What makes these MCP libraries different?
These MCP Libraries are built using the proprietary BRiTeCycle® platform, enabling the creation of structurally diverse, non-canonical macrocyclic peptides. This approach offers:
- Enhanced Diversity: Access to 10,000+ unique peptides synthesized from over 60 α-, β-, and γ-amino acid building blocks (out of the 1,000's available), including N-alkylated and cyclic structures.
- Optimized Screening: Libraries designed for compatibility with both phenotypic assays and mass spectrometry-based workflows.
- Rapid Turnaround: Made-to-order libraries with lead times as short as 3–4 weeks for 2,304 MCP.
What is BRiTeCycle®?
What is BRiTeCycle®?
BRiTeCycle® is a novel synthesis engine developed by experienced medicinal chemists. It enables the creation of macrocyclic peptides beyond the capabilities of standard SPPS or mRNA display methods, expanding access to non-canonical structures and high-diversity scaffolds. This platform has already demonstrated significant impact, with 10,000 macrocycles synthesized, delivered, and screened by NIH/NCATS.
How much material is provided per compound?
How much material is provided per compound?
Each compound can be offered in microgram scale, which is standard for high-throughput screening. Larger quantities can be provided through resynthesis if needed.
Are custom formats or layouts available?
Are custom formats or layouts available?
Yes, libraries can be delivered in discrete or pooled formats, including 384-well plates. Custom plating and barcoding options are available upon request to suit your specific needs.
How does this ship?
How does this ship?
Can ship on dry ice, overnight.
What are the lead times?
What are the lead times?
- 2,300-compound library: Approximately 3–4 weeks
- 10,000-compound library: Approximately 6–8 weeks
All libraries are made-to-order to ensure they meet your specific requirements.
Is pricing listed online?
Is pricing listed online?
World-class macrocyclic peptide libraries at a price that scales with your science. Custom library pricing ranges from $30–$100/MCP — the larger the library, the lower the per-compound cost.
Pricing is based on a typical 12-mer MCP with head-to-tail cyclization. Ready to find the right fit for your budget and your research? Request a Quote and our team will tailor a pricing plan to your specific library size and screening needs.
How does fulfillment work?
How does fulfillment work?
Orders are placed through Chem-Impex, and libraries ship directly from BRT Biotechnologies in Claremont, CA. Shipping options include overnight delivery on dry ice to maintain compound stability.
Can I talk to someone about library fit before ordering?
Can I talk to someone about library fit before ordering?
Absolutely. Each inquiry includes a scientific consultation to help you choose the right library and support services tailored to your assay and screening needs. Book a time to chat with our team here.
Are these libraries suited for academic labs?
Are these libraries suited for academic labs?
Yes, these libraries are designed for use in biotech, pharma, and academic discovery. They are particularly useful for exploring novel mechanisms of action and targeting hard-to-drug proteins.
What is the return policy?
What is the return policy?
Due to the custom nature of these libraries, no cancellations, refunds, or returns are allowed once an order is placed.
Book a free consultation with our team
Need help understanding if these libraries are the right fit for your project? Our technical team will answer any questions and walk you through your options!