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Catalog Number:
02429
CAS Number:
76542-83-1
Fmoc-L-leucine N-hydroxysuccinimide ester
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-Leu-OSu, (S)-Fmoc-2-amino-4-methylpentanoic acid N-hydroxysuccinimideester
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Product Information

Fmoc-L-leucine N-hydroxysuccinimide ester is a versatile compound widely utilized in peptide synthesis and drug development. This derivative of leucine, featuring a fluorenylmethoxycarbonyl (Fmoc) protecting group, offers enhanced stability and ease of handling during the synthesis process. Its unique structure allows for selective coupling reactions, making it an ideal choice for researchers looking to construct complex peptide sequences efficiently. The N-hydroxysuccinimide ester functionality further enhances its reactivity, facilitating the formation of amide bonds with amino acids or other nucleophiles, thus streamlining the synthesis of bioactive peptides.

This compound is particularly valuable in the pharmaceutical industry, where it is employed in the development of peptide-based therapeutics and vaccines. Its ability to provide high yields and purity in peptide synthesis makes it a preferred choice among chemists and researchers. Additionally, Fmoc-L-leucine N-hydroxysuccinimide ester can be used in various applications, including the production of peptide libraries for drug discovery and the synthesis of targeted delivery systems. Its compatibility with automated synthesizers also enhances its appeal, allowing for high-throughput applications in research and development.

Synonyms
Fmoc-L-Leu-OSu, (S)-Fmoc-2-amino-4-methylpentanoic acid N-hydroxysuccinimideester
CAS Number
76542-83-1
Purity
≥ 98% (HPLC)
Molecular Formula
C25H26N2O6
Molecular Weight
450.5
MDL Number
MFCD00065659
Melting Point
120 - 125 °C
Appearance
White powder
Optical Rotation
[a]D20 = -37 ± 2 º (C=1 in AcOH)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Leu-OSu, (S)-Fmoc-2-amino-4-methylpentanoic acid N-hydroxysuccinimideester
CAS Number
76542-83-1
Purity
≥ 98% (HPLC)
Molecular Formula
C25H26N2O6
Molecular Weight
450.5
MDL Number
MFCD00065659
Melting Point
120 - 125 °C
Appearance
White powder
Optical Rotation
[a]D20 = -37 ± 2 º (C=1 in AcOH)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-leucine N-hydroxysuccinimide ester is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing researchers to create complex molecules with specific sequences for various applications in drug development.
  • Bioconjugation: It is employed in bioconjugation processes, where it helps attach biomolecules to other entities, enhancing the functionality of drugs and diagnostic agents.
  • Drug Delivery Systems: The compound is used in formulating advanced drug delivery systems, improving the stability and bioavailability of therapeutic agents, which is crucial for effective treatment.
  • Research in Cancer Therapy: Its application in developing targeted therapies for cancer showcases its importance, as it aids in creating compounds that can selectively attack cancer cells while sparing healthy ones.
  • Protein Engineering: In protein engineering, it facilitates the modification of proteins, allowing scientists to study protein interactions and functions, which is vital for understanding biological processes.