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Catalog Number:
32472
CAS Number:
78287-27-1
7-Éthylcamptothécine
Purity:
≥ 99 % (HPLC)
Synonym(s):
(4 S )-4,11-diéthyl-4-hydroxy-1 H -pyrano[3',4':6,7]indolizino[1,2-b]quinoléine-3,14(4 H ,12 H )-dione
Hazmat
Documents
$51.18 /250 mg
Taille
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Product Information

Conserver le récipient bien fermé dans un endroit sec et bien aéré.

Synonyms
(4 S )-4,11-diéthyl-4-hydroxy-1 H -pyrano[3',4':6,7]indolizino[1,2-b]quinoléine-3,14(4 H ,12 H )-dione
CAS Number
78287-27-1
Purity
≥ 99 % (HPLC)
Molecular Formula
C22H20N2O4
Molecular Weight
376.41
MDL Number
MFCD06657922
PubChem ID
9810521
Melting Point
258 - 260 °C (déc.)
Appearance
Poudre cristalline en forme d'aiguilles jaune pâle
Optical Rotation
[a]20/D= 40 à 46 ° (C=0,4 dans CHCl3:MeOH=8:2)
Conditions
Magasin chez RT
General Information
Synonyms
(4 S )-4,11-diéthyl-4-hydroxy-1 H -pyrano[3',4':6,7]indolizino[1,2-b]quinoléine-3,14(4 H ,12 H )-dione
CAS Number
78287-27-1
Purity
≥ 99 % (HPLC)
Molecular Formula
C22H20N2O4
Molecular Weight
376.41
MDL Number
MFCD06657922
PubChem ID
9810521
Melting Point
258 - 260 °C (déc.)
Appearance
Poudre cristalline en forme d'aiguilles jaune pâle
Optical Rotation
[a]20/D= 40 à 46 ° (C=0,4 dans CHCl3:MeOH=8:2)
Conditions
Magasin chez RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Oui
Antibiotic
Non
DEA-regulated
Non
Warnings
-
Applications

7-Ethylcamptothecin is widely utilized in research focused on:

  • Cancer Treatment: This compound is a potent inhibitor of topoisomerase I, making it a valuable candidate in the development of anti-cancer therapies. It has shown promising results in clinical trials for various cancers, including colorectal and lung cancer.
  • Pharmaceutical Development: Researchers are exploring its potential in formulating new drugs that can overcome resistance seen with traditional chemotherapy agents. Its unique structure allows for modifications that can enhance efficacy and reduce side effects.
  • Drug Delivery Systems: Due to its hydrophobic nature, 7-Ethylcamptothecin can be incorporated into nanocarriers for targeted drug delivery, improving the concentration of the drug at tumor sites while minimizing systemic exposure.
  • Research on Mechanisms of Action: Scientists use this compound to study the mechanisms of DNA damage and repair, providing insights into cellular responses to chemotherapy and helping to identify biomarkers for treatment efficacy.
  • Combination Therapies: It is being investigated in combination with other therapeutic agents to enhance overall treatment outcomes, particularly in resistant cancer types, showcasing its versatility in oncology.

Citations