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Catalog Number:
38838
CAS Number:
54-62-6
Aminoptérine
Grade:
Convient à la culture cellulaire
Purity:
≥ 97 % (CCM)
Synonym(s):
4-Amino-Pga, Acide 4-aminofolique, Acide 4-aminoptéroyl-L-glutamique
Hazmat
Documents
$88.33 /10 mg
Taille
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Informations sur le produit

Aminopterin is a potent antifolate compound primarily recognized for its role in cancer therapy and as an immunosuppressant. This versatile chemical is a derivative of pteridine and is structurally related to methotrexate, making it valuable in the treatment of various malignancies, including leukemia and certain solid tumors. Its mechanism of action involves the inhibition of dihydrofolate reductase, which is crucial for DNA synthesis and cell division, thereby effectively slowing down the proliferation of rapidly dividing cancer cells.

In addition to its oncological applications, Aminopterin has been utilized in research settings to study folate metabolism and the effects of folate deficiency. Its unique properties allow researchers to explore its potential in combination therapies, enhancing the efficacy of other anticancer agents. With a strong track record in both clinical and laboratory environments, Aminopterin continues to be a significant compound for professionals seeking effective solutions in cancer treatment and biological research.

Numéro CAS 
54-62-6
Formule moléculaire
C19H20N8O5
Poids moléculaire 
440.42
Point de fusion 
221 - 223 ?C
Informations générales
Numéro CAS 
54-62-6
Formule moléculaire
C19H20N8O5
Poids moléculaire 
440.42
Point de fusion 
221 - 223 ?C
Propriétés
Informations complémentaires sur la propriété à venir prochainement !
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Sécurité et réglementation
Matières dangereuses
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Antibiotique
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Réglementé par la DEA
Non
Avertissements 
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Applications

Aminopterin is widely utilized in research focused on:

  • Cancer Treatment: It is used as a chemotherapy agent, particularly in the treatment of leukemia, where it helps inhibit cell division and growth of cancer cells.
  • Autoimmune Disease Research: Aminopterin plays a role in studying autoimmune diseases by suppressing the immune response, allowing researchers to explore therapeutic options.
  • Cell Culture Studies: In laboratory settings, it is employed to select for cells that are resistant to antifolates, aiding in the development of new drugs and therapies.
  • Genetic Research: It is used in genetic studies to induce mutations in model organisms, providing insights into gene function and disease mechanisms.
  • Pharmaceutical Development: The compound is valuable in the development of new antifolate drugs, offering a basis for creating more effective treatments with fewer side effects.

Citations