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Catalog Number:
02665
CAS Number:
112883-42-8
Fmoc- N -méthyl-L-norleucine
Purity:
≥ 99,5 % (HPLC chirale)
Synonym(s):
Fmoc-N-Me-L-Nle-OH, Acide Fmoc- N -méthyl-L-2-aminohexanoïque
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Product Information

Fmoc-N-methyl-L-norleucine is a valuable amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during the synthesis of peptides. Its unique structure allows for enhanced stability and solubility, making it an ideal choice for researchers focused on developing complex peptide sequences. Fmoc-N-methyl-L-norleucine is particularly advantageous in solid-phase peptide synthesis (SPPS), where it contributes to the efficiency and yield of the final product.

In addition to its role in peptide synthesis, this compound is also explored in the development of pharmaceuticals and biologically active compounds, where its properties can lead to improved bioavailability and efficacy. Researchers appreciate its versatility and effectiveness, especially when compared to other amino acid derivatives. With its robust applications in both academic and industrial settings, Fmoc-N-methyl-L-norleucine stands out as a crucial tool for advancing peptide chemistry and drug discovery.

Synonyms
Fmoc-N-Me-L-Nle-OH, Acide Fmoc- N -méthyl-L-2-aminohexanoïque
CAS Number
112883-42-8
Purity
≥ 99,5 % (HPLC chirale)
Molecular Formula
C 22 H 254
Molecular Weight
367.4
MDL Number
MFCD00235878
PubChem ID
4259757
Melting Point
112 - 125 ºC
Appearance
Poudre blanche à blanc cassé
Optical Rotation
[a] D 20 = -22 ± 2 º (C = 1 dans DMF)
Conditions
Conserver à 0 - 8 °C
General Information
Synonyms
Fmoc-N-Me-L-Nle-OH, Acide Fmoc- N -méthyl-L-2-aminohexanoïque
CAS Number
112883-42-8
Purity
≥ 99,5 % (HPLC chirale)
Molecular Formula
C 22 H 254
Molecular Weight
367.4
MDL Number
MFCD00235878
PubChem ID
4259757
Melting Point
112 - 125 ºC
Appearance
Poudre blanche à blanc cassé
Optical Rotation
[a] D 20 = -22 ± 2 º (C = 1 dans DMF)
Conditions
Conserver à 0 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
Non
Antibiotic
Non
DEA-regulated
Non
Warnings
-
Applications

Fmoc-N-methyl-L-norleucine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the creation of complex peptide sequences with high purity.
  • Drug Development: It plays a role in the design of peptide-based pharmaceuticals, where its unique structure can enhance the stability and bioactivity of therapeutic peptides.
  • Bioconjugation: Fmoc-N-methyl-L-norleucine is used in bioconjugation techniques, facilitating the attachment of peptides to various biomolecules, which is essential for developing targeted drug delivery systems.
  • Research in Protein Engineering: Researchers utilize this compound to modify proteins, enabling the exploration of structure-function relationships and the development of novel protein therapeutics.
  • Analytical Chemistry: It is employed in analytical methods to study peptide interactions and stability, providing insights that are crucial for both academic research and industrial applications.

Citations