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Catalog Number:
02449
CAS Number:
86060-90-4
Ester pentafluorophénylique de Fmoc-L-proline
Purity:
≥ 99 % (HPLC)
Synonym(s):
Fmoc-L-Pro-OPfp, ( Ester pentafluorophénylique de l'acide S -Fmoc-pyrrolidine-2-carboxylique
Documents
$29.34 /1G
Taille
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Informations sur le produit

Fmoc-L-proline pentafluorophenyl ester is a versatile and highly valuable compound in the field of peptide synthesis and medicinal chemistry. This compound serves as a protective group for amino acids, particularly in the solid-phase peptide synthesis process, where it enhances the stability and solubility of the intermediates. Its unique structure, featuring a fluorenylmethoxycarbonyl (Fmoc) group, allows for easy removal under mild conditions, making it an ideal choice for researchers looking to streamline their synthesis workflows.

Moreover, the incorporation of the pentafluorophenyl moiety not only increases the lipophilicity of the compound but also improves its reactivity, making it suitable for a variety of applications in drug development and bioconjugation. Researchers have successfully utilized Fmoc-L-proline pentafluorophenyl ester in the synthesis of bioactive peptides and complex natural products, showcasing its potential in developing therapeutics with enhanced efficacy. Its ability to facilitate the formation of peptide bonds while maintaining the integrity of the amino acid structure positions it as a crucial tool for professionals in the pharmaceutical and biotechnology sectors.

Numéro CAS 
86060-90-4
Formule moléculaire
C 26 H 18 NON 4 F 5
Poids moléculaire 
503.4
Point de fusion 
122-130 ºC
Rotation optique 
[a] D 20 = -57 à -64º (c=1% dans CHCl3)
Informations générales
Numéro CAS 
86060-90-4
Formule moléculaire
C 26 H 18 NON 4 F 5
Poids moléculaire 
503.4
Point de fusion 
122-130 ºC
Rotation optique 
[a] D 20 = -57 à -64º (c=1% dans CHCl3)
Propriétés
Informations complémentaires sur la propriété à venir prochainement !
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Sécurité et réglementation
Matières dangereuses
-
Antibiotique
-
Réglementé par la DEA
Non
Avertissements 
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Applications

Fmoc-L-proline pentafluorophenyl ester is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing for the introduction of proline residues with high efficiency and specificity.
  • Drug Development: It is used in the design of pharmaceutical compounds, particularly in creating peptide-based drugs that target specific biological pathways, enhancing therapeutic efficacy.
  • Bioconjugation: The ester can be employed in bioconjugation techniques, linking biomolecules to surfaces or other molecules, which is crucial in developing biosensors and drug delivery systems.
  • Research in Protein Engineering: It aids researchers in modifying proteins to study structure-function relationships, providing insights into protein behavior and interactions.
  • Fluorinated Compound Applications: The presence of fluorine enhances the stability and bioavailability of compounds, making it valuable in various applications in medicinal chemistry.

Citations