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Catalog Number:
22870
CAS Number:
2390-54-7
Thioflavine T
Purity:
≥ 90 % (teneur en colorant)
Synonym(s):
Basic Yellow 1 , CI 49005 
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Product Information

Thioflavin T is a highly regarded fluorescent dye known for its exceptional ability to bind to amyloid fibrils, making it an invaluable tool in the study of neurodegenerative diseases such as Alzheimer's. This compound exhibits strong fluorescence properties, allowing researchers to visualize and quantify amyloid deposits in biological samples with high sensitivity. Its unique structure, featuring a benzothiazole moiety, enhances its binding affinity to misfolded proteins, providing a reliable method for detecting amyloid aggregates in tissue sections and cell cultures.

In addition to its applications in biomedical research, Thioflavin T is also utilized in various industries for quality control and material characterization. Its ability to indicate the presence of specific protein conformations makes it a useful agent in the development of therapeutic strategies targeting amyloid-related pathologies. With its proven track record in both research and industrial applications, Thioflavin T stands out as a critical reagent for scientists and professionals seeking to advance their understanding of protein misfolding and aggregation.

Synonyms
Basic Yellow 1 , CI 49005 
CAS Number
2390-54-7
Purity
≥ 90 % (teneur en colorant)
Molecular Formula
C17H19N2SCl
Molecular Weight
318.87
MDL Number
MFCD00011944
PubChem ID
16953
Appearance
Poudre jaune ou jaune d'or
Conditions
Magasin chez RT
General Information
Synonyms
Basic Yellow 1 , CI 49005 
CAS Number
2390-54-7
Purity
≥ 90 % (teneur en colorant)
Molecular Formula
C17H19N2SCl
Molecular Weight
318.87
MDL Number
MFCD00011944
PubChem ID
16953
Appearance
Poudre jaune ou jaune d'or
Conditions
Magasin chez RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Non
Antibiotic
Non
DEA-regulated
Non
Warnings
-
Applications

Thioflavin T is widely utilized in research focused on:

  • Protein Aggregation Studies: It is commonly used as a fluorescent dye to detect amyloid fibrils in various neurodegenerative diseases, helping researchers understand conditions like Alzheimer's.
  • Cellular Imaging: This compound is employed in live-cell imaging to visualize cellular structures and processes, providing insights into cell behavior and function.
  • Drug Discovery: Thioflavin T is valuable in screening potential drug candidates that target protein misfolding, aiding pharmaceutical companies in developing effective treatments.
  • Environmental Monitoring: It can be used to assess the presence of certain pollutants in water samples, contributing to environmental safety and compliance.
  • Biomarker Development: The compound plays a role in the identification of biomarkers for various diseases, enhancing diagnostic capabilities in clinical settings.

Citations