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Catalog Number:
38123
CAS Number:
123653-11-2
NS-398
Purity:
≥ 98 % (HPLC)
Synonym(s):
N- [2-(cyclohexyloxy)-4-nitrophényl]méthanesulfonamide
Documents
$205.61 /10 mg
Taille
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Informations sur le produit

NS-398 is a potent and selective inhibitor of cyclooxygenase-2 (COX-2), making it a valuable compound in both pharmaceutical research and therapeutic applications. With its unique structure, characterized by the presence of a cyclohexyloxy group and a nitrophenyl moiety, NS-398 has been extensively studied for its anti-inflammatory and analgesic properties. This compound is particularly relevant in the development of non-steroidal anti-inflammatory drugs (NSAIDs), offering a targeted approach to pain management and inflammation reduction without the gastrointestinal side effects commonly associated with traditional NSAIDs.

Researchers have utilized NS-398 in various studies to explore its efficacy in treating conditions such as arthritis, cancer, and cardiovascular diseases. Its selectivity for COX-2 over COX-1 allows for a more favorable safety profile, making it an attractive candidate for further development in pain relief therapies. The compound's ability to modulate inflammatory pathways positions it as a significant player in the ongoing search for safer and more effective anti-inflammatory agents.

Numéro CAS 
123653-11-2
Formule moléculaire
C13H18N2O5S
Poids moléculaire 
314.36
Point de fusion 
137 - 141 °C
Informations générales
Numéro CAS 
123653-11-2
Formule moléculaire
C13H18N2O5S
Poids moléculaire 
314.36
Point de fusion 
137 - 141 °C
Propriétés
Informations complémentaires sur la propriété à venir prochainement !
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Sécurité et réglementation
Matières dangereuses
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Antibiotique
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Réglementé par la DEA
Non
Avertissements 
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Applications

NS-398 is widely utilized in research focused on:

  • Pain Management: This compound acts as a selective inhibitor of cyclooxygenase-2 (COX-2), making it valuable in developing anti-inflammatory medications that target pain relief without the gastrointestinal side effects associated with non-selective NSAIDs.
  • Cancer Research: NS-398 has shown potential in inhibiting tumor growth in various cancer models, providing researchers with a tool to explore COX-2's role in cancer progression and the development of new therapies.
  • Cardiovascular Studies: By selectively inhibiting COX-2, NS-398 is used in studies examining its effects on cardiovascular health, helping to understand the balance between inflammation and heart disease.
  • Neuroprotection: Research indicates that NS-398 may offer neuroprotective benefits, making it a candidate for studies aimed at treating neurodegenerative diseases like Alzheimer's and Parkinson's.
  • Drug Development: As a lead compound, NS-398 serves as a model for synthesizing new COX-2 inhibitors, aiding pharmaceutical companies in creating safer and more effective anti-inflammatory drugs.

Citations