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Catalog Number:
37608
CAS Number:
54301-15-4
Chlorhydrate d'amsacrine
Purity:
≥ 98 % (HPLC)
Synonym(s):
Chlorhydrate de 4-(9-acridinylamino) -N- (méthanesulfonyl)-m-anisidine, m-AMSA
Hazmat
Documents
$168.35 /20 mg
Taille
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Informations sur le produit

Amsacrine hydrochloride is a potent anthracycline derivative known for its significant role in cancer therapy, particularly in the treatment of acute lymphoblastic leukemia and other hematological malignancies. This compound exhibits a unique mechanism of action by intercalating into DNA, thereby inhibiting topoisomerase II, which is crucial for DNA replication and repair. Its efficacy in clinical settings has made it a valuable agent in combination therapies, enhancing the overall effectiveness of treatment regimens.

Researchers and industry professionals appreciate Amsacrine hydrochloride for its ability to overcome drug resistance often seen with other chemotherapeutic agents. Its targeted action and favorable pharmacological profile make it a preferred choice in oncology research and drug development. Additionally, its applications extend to laboratory settings, where it serves as a vital tool for studying cellular processes and drug interactions. With ongoing research into its potential uses, Amsacrine hydrochloride continues to hold promise for advancing cancer treatment strategies.

Numéro CAS 
54301-15-4
Formule moléculaire
C21H19N3O3S · HCl
Poids moléculaire 
429.92
Point de fusion 
288 ?C
Informations générales
Numéro CAS 
54301-15-4
Formule moléculaire
C21H19N3O3S · HCl
Poids moléculaire 
429.92
Point de fusion 
288 ?C
Propriétés
Informations complémentaires sur la propriété à venir prochainement !
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Sécurité et réglementation
Matières dangereuses
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Antibiotique
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Réglementé par la DEA
Non
Avertissements 
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Applications

Amsacrine hydrochloride is widely utilized in research focused on:

  • Cancer Treatment: This compound is primarily used as an antineoplastic agent in chemotherapy, particularly for treating acute leukemia. Its ability to intercalate DNA helps inhibit cancer cell proliferation.
  • Pharmaceutical Development: Researchers explore its efficacy in combination therapies, enhancing the effectiveness of other anticancer drugs, which can lead to improved patient outcomes.
  • Cellular Mechanism Studies: Amsacrine hydrochloride is valuable in laboratory studies investigating cellular mechanisms of drug resistance, helping scientists understand how cancer cells evade treatment.
  • Drug Formulation Research: The compound is used in developing new drug formulations, focusing on improving bioavailability and reducing side effects, which is crucial for patient compliance.
  • Biochemical Assays: It serves as a tool in various biochemical assays to study DNA interactions and the effects of DNA damage, providing insights into fundamental biological processes.

Citations