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Catalog Number:
38166
CAS Number:
57-66-9
Probénécide
Purity:
≥ 98 % (dosage par titration, HPLC)
Synonym(s):
Acide 4-( N,N -Dipropylsulfamoyl)benzoïque, Acide 4-(di- n -propylaminosulfonyl)benzoïque
Documents
$79.22 /25G
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Informations sur le produit

Probenecid is a versatile compound primarily recognized for its role as a uricosuric agent in the treatment of gout and hyperuricemia. This sulfonamide derivative enhances the excretion of uric acid by inhibiting its reabsorption in the renal tubules, making it a valuable tool in managing conditions associated with elevated uric acid levels. Beyond its therapeutic applications, Probenecid is also utilized in pharmaceutical formulations to prolong the action of certain antibiotics, such as penicillin, by inhibiting their renal excretion. This dual functionality makes Probenecid an essential compound in both clinical and research settings.

In addition to its medicinal uses, Probenecid's unique properties allow for its application in various biochemical studies, particularly in the exploration of renal transport mechanisms. Researchers appreciate its ability to modulate drug pharmacokinetics, which can lead to enhanced therapeutic outcomes. With its established efficacy and broad applicability, Probenecid continues to be an important compound for healthcare professionals and researchers alike, offering significant benefits in both treatment and scientific exploration.

Numéro CAS 
57-66-9
Formule moléculaire
C 13 H 19 NON 4 S
Poids moléculaire 
285.36
Point de fusion 
198 - 202 °C
Informations générales
Numéro CAS 
57-66-9
Formule moléculaire
C 13 H 19 NON 4 S
Poids moléculaire 
285.36
Point de fusion 
198 - 202 °C
Propriétés
Informations complémentaires sur la propriété à venir prochainement !
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Sécurité et réglementation
Matières dangereuses
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Antibiotique
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Réglementé par la DEA
Non
Avertissements 
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Applications

Probenecid is widely utilized in research focused on

  • Gout Treatment: Probenecid is primarily used to manage gout by increasing uric acid excretion in the kidneys, helping to lower uric acid levels in the blood and prevent painful flare-ups.
  • Enhancing Antibiotic Efficacy: In clinical settings, it is employed to prolong the action of certain antibiotics, such as penicillin, by inhibiting their renal excretion, thus allowing for lower doses and reduced side effects.
  • Pharmacokinetic Studies: Researchers use probenecid in pharmacokinetic studies to understand drug interactions and metabolism, particularly in assessing how drugs are absorbed, distributed, and eliminated by the body.
  • Research on Renal Function: It serves as a valuable tool in nephrology research, helping scientists investigate renal function and the mechanisms of renal transport processes.
  • Potential Cancer Research: Emerging studies suggest probenecid may have applications in cancer therapy, as it can influence the transport of certain anticancer drugs, potentially enhancing their effectiveness.

Citations