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Catalog Number:
38020
CAS Number:
141505-33-1
Lévosimendan
Purity:
98,5 - 102,0 % (HPLC)
Synonym(s):
( R )-Simendan, 2-[2-[4-[(4R)-1,4,5,6-tétrahydro-4-méthyl-6-oxo-3-pyridazinyl]phényl]hydrazinylidène]-propanedinitrile
Documents
$32.75 /100 mg
Taille
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Informations sur le produit

Levosimendan is a novel inotropic agent primarily used in the management of acute heart failure. This compound enhances cardiac contractility without significantly increasing myocardial oxygen demand, making it particularly beneficial for patients with compromised cardiac function. Levosimendan operates through a dual mechanism: it sensitizes the heart to calcium and also acts as a vasodilator, which can lead to improved hemodynamics and reduced pulmonary congestion. Its unique properties make it a valuable option in critical care settings, especially for patients who may not respond adequately to traditional therapies.

In clinical practice, Levosimendan has been shown to improve symptoms and outcomes in patients with severe heart failure, particularly during acute exacerbations. Its ability to provide both inotropic support and vasodilation sets it apart from other agents, offering a comprehensive approach to treatment. Researchers and healthcare professionals appreciate its rapid onset of action and favorable safety profile, making it a preferred choice in acute settings. With ongoing studies exploring its potential in chronic heart failure and other cardiovascular conditions, Levosimendan holds promise for expanding therapeutic options in cardiac care.

Numéro CAS 
141505-33-1
Formule moléculaire
C14H12N6O
Poids moléculaire 
280.29
Point de fusion 
204 - 206 °C
Rotation optique 
[a] 20 D = -548 à -582 °
Informations générales
Numéro CAS 
141505-33-1
Formule moléculaire
C14H12N6O
Poids moléculaire 
280.29
Point de fusion 
204 - 206 °C
Rotation optique 
[a] 20 D = -548 à -582 °
Propriétés
Informations complémentaires sur la propriété à venir prochainement !
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Sécurité et réglementation
Matières dangereuses
-
Antibiotique
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Réglementé par la DEA
Non
Avertissements 
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Applications

Levosimendan is widely utilized in research focused on:

  • Heart Failure Treatment: This compound is primarily used in managing acute heart failure. It enhances cardiac contractility without significantly increasing myocardial oxygen demand, making it a valuable option for patients with compromised heart function.
  • Cardiovascular Research: Researchers use levosimendan to study its effects on cardiac muscle function and its potential benefits in various cardiovascular diseases, providing insights into new therapeutic strategies.
  • Clinical Trials: Levosimendan is often involved in clinical trials aimed at evaluating its efficacy and safety in different patient populations, helping to advance medical knowledge and treatment options.
  • Combination Therapies: In some cases, it is used in combination with other medications to enhance overall treatment effectiveness for heart failure, offering a multi-faceted approach to patient care.
  • Pharmacological Studies: The compound serves as a model in pharmacological studies to understand the mechanisms of action of inotropic agents, aiding in the development of new drugs with improved profiles.

Citations